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Fas (TNF receptor superfamily member 6) (Q21494938)

From Wikidata
mammalian protein found in Mus musculus
  • Fas antigen
  • lymphoproliferation
  • apoptosis-mediating surface antigen FAS
  • tumor necrosis factor receptor superfamily member 6
  • Fas (TNF receptor superfamily member)
  • FASLG receptor
  • apo-1 antigen
  • Fas
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    English
    Fas (TNF receptor superfamily member 6)
    mammalian protein found in Mus musculus
    • Fas antigen
    • lymphoproliferation
    • apoptosis-mediating surface antigen FAS
    • tumor necrosis factor receptor superfamily member 6
    • Fas (TNF receptor superfamily member)
    • FASLG receptor
    • apo-1 antigen
    • Fas

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    12 references
    retrieved
    8 April 2019
    stated in
    Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions
    GOA
    curator
    UniProt
    UniProt protein ID
    P25446
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation
    GOA
    curator
    UniProt
    UniProt protein ID
    P25446
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Palmitoylation is required for efficient Fas cell death signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IPI
    cell component
    external side of plasma membrane
    determination method or standard
    IDA
    6 references
    retrieved
    8 April 2019
    stated in
    Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    biological process
    extrinsic apoptotic signaling pathway via death domain receptors
    determination method or standard
    IMP
    IDA
    IGI
    12 references
    retrieved
    8 April 2019
    stated in
    Several different cell surface molecules control negative selection of medullary thymocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25446
    determination method or standard
    IDA

    Identifiers

     
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