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Myeloid cell leukemia sequence 1 (Q21428169)

From Wikidata
mammalian protein found in Mus musculus
  • bcl-2-related protein EAT/mcl1
  • Mcl1
  • induced myeloid leukemia cell differentiation protein Mcl-1 homolog
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    English
    Myeloid cell leukemia sequence 1
    mammalian protein found in Mus musculus
    • bcl-2-related protein EAT/mcl1
    • Mcl1
    • induced myeloid leukemia cell differentiation protein Mcl-1 homolog

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    10 references
    retrieved
    14 February 2019
    stated in
    Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins
    GOA
    curator
    UniProt
    UniProt protein ID
    P97287
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    P97287
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Structural insights into the degradation of Mcl-1 induced by BH3 domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    BH3 domains other than Bim and Bid can directly activate Bax/Bak
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97287
    determination method or standard
    IPI
    cell component
    biological process
    Commons category
    Myeloid cell leukemia sequence 1 protein
    0 references

    Identifiers

     
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