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Mediator complex subunit 1 (Q21173409)

From Wikidata
mammalian protein found in Homo sapiens
  • MED1
  • activator-recruited cofactor 205 kDa component
  • vitamin D receptor-interacting protein complex component DRIP205
  • Trap220
  • p53 regulatory protein RB18A
  • TR-interacting protein 2
  • Thyroid receptor-interacting protein 2
  • thyroid receptor interacting protein 2
  • mediator of RNA polymerase II transcription subunit 1
  • PBP
  • peroxisome proliferator-activated receptor-binding protein
  • thyroid hormone receptor-associated protein complex component TRAP220
  • vitamin D receptor-interacting protein 230 kD
  • PPAR-binding protein
  • ARC205
  • TRIP-2
  • PPARG binding protein
  • thyroid hormone receptor-associated protein complex 220 kDa component
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    English
    Mediator complex subunit 1
    mammalian protein found in Homo sapiens
    • MED1
    • activator-recruited cofactor 205 kDa component
    • vitamin D receptor-interacting protein complex component DRIP205
    • Trap220
    • p53 regulatory protein RB18A
    • TR-interacting protein 2
    • Thyroid receptor-interacting protein 2
    • thyroid receptor interacting protein 2
    • mediator of RNA polymerase II transcription subunit 1
    • PBP
    • peroxisome proliferator-activated receptor-binding protein
    • thyroid hormone receptor-associated protein complex component TRAP220
    • vitamin D receptor-interacting protein 230 kD
    • PPAR-binding protein
    • ARC205
    • TRIP-2
    • PPARG binding protein
    • thyroid hormone receptor-associated protein complex 220 kDa component

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    10 references
    retrieved
    8 April 2019
    stated in
    The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CCAR1/CoCoA pair‐mediated recruitment of the Mediator defines a novel pathway for GATA1 function
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Enhancer activation requires trans-recruitment of a mega transcription factor complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Subunit architecture and functional modular rearrangements of the transcriptional mediator complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    transcription coactivator activity
    determination method or standard
    IDA
    IEA
    IMP
    TAS
    8 references
    retrieved
    8 April 2019
    stated in
    Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    CCAR1/CoCoA pair‐mediated recruitment of the Mediator defines a novel pathway for GATA1 function
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    vitamin D receptor binding
    determination method or standard
    IBA
    IEA
    IPI
    NAS
    TAS
    5 references
    retrieved
    8 April 2019
    stated in
    Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IBA
    cell component
    nucleus
    determination method or standard
    IDA
    IEA
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Composite co-activator ARC mediates chromatin-directed transcriptional activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    mediator complex
    determination method or standard
    IDA
    IEA
    IMP
    6 references
    retrieved
    17 October 2017
    stated in
    MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
    determination method or standard
    IMP
    retrieved
    17 October 2017
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    17 October 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    17 October 2017
    stated in
    Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15648&geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    mediator complex
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    7 references
    retrieved
    8 April 2019
    stated in
    MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IBA
    biological process
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IDA
    IEA
    IMP
    7 references
    retrieved
    8 April 2019
    stated in
    MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15648
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15648
    determination method or standard
    IDA

    Identifiers

    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q21173409&oldid=2426564984"