Eukaryotic translation initiation factor 4E (Q21172259)

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mammalian protein found in Homo sapiens
  • eukaryotic translation initiation factor 4E
  • mRNA cap-binding protein
  • EIF4E
  • eukaryotic translation initiation factor 4E-like 1
  • eIF-4F 25 kDa subunit
  • EIF4E protein, human
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Language Label Description Also known as
English
Eukaryotic translation initiation factor 4E
mammalian protein found in Homo sapiens
  • eukaryotic translation initiation factor 4E
  • mRNA cap-binding protein
  • EIF4E
  • eukaryotic translation initiation factor 4E-like 1
  • eIF-4F 25 kDa subunit
  • EIF4E protein, human

Statements

molecular function
protein binding
determination method
IPI
31 references
retrieved
8 April 2019
stated in
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Rbm24, a target of p53, is necessary for proper expression of p53 and heart development.
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Sumoylation of eIF4E activates mRNA translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
eIF4G is required for the pioneer round of translation in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
An empirical framework for binary interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of mammalian eIF4E-family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5' cap
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
An oxygen-regulated switch in the protein synthesis machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of human eIF4E by 4E-BP1: binding analysis using surface plasmon resonance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
retrieved
8 April 2019
stated in
Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IPI
translation initiation factor activity
determination method
IBA
IDA
IEA
ISS
TAS
7 references
retrieved
8 April 2019
stated in
Amino acid sequence of the mRNA cap-binding protein from human tissues
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IEA
retrieved
8 April 2019
stated in
Translational homeostasis via the mRNA cap-binding protein, eIF4E
GOA
curator
UniProt
UniProt protein ID
P06730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06730
determination method
IBA
cell component
biological process

Identifiers

MeSH descriptor ID
C000632169
subject named as
EIF4E protein, human
0 references
PDB structure ID
 
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