Glutathione S-transferase mu 2 (Q21146254)

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mammalian protein found in Homo sapiens

glutathione S-transferase Mu 2
glutathione S-alkyltransferase M2
glutathione S-transferase mu 2 (muscle)
GST, muscle
epididymis secretory sperm binding protein
GSTM2-2
glutathione S-transferase M2 (muscle)
S-(hydroxyalkyl)glutathione lyase M2
glutathione S-aralkyltransferase M2
glutathione S-aryltransferase M2
glutathione S-transferase 4
GST class-mu 2
GSTM2
glutathione S-transferase M1

Language	Label	Description	Also known as
English	Glutathione S-transferase mu 2	mammalian protein found in Homo sapiens	glutathione S-transferase Mu 2 glutathione S-alkyltransferase M2 glutathione S-transferase mu 2 (muscle) GST, muscle epididymis secretory sperm binding protein GSTM2-2 glutathione S-transferase M2 (muscle) S-(hydroxyalkyl)glutathione lyase M2 glutathione S-aralkyltransferase M2 glutathione S-aryltransferase M2 glutathione S-transferase 4 GST class-mu 2 GSTM2 glutathione S-transferase M1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Thioredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28161

Glutathione S-transferase, Mu class

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28161

Glutathione S-transferase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28161

Glutathione S-transferase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glutathione S-transferase, C-terminal-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glutathione S-transferase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

glutathione binding

determination method

protein binding

determination method

1 reference

9 May 2019

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

determination method

1 reference

9 May 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

signaling receptor binding

determination method

1 reference

9 May 2019

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

glutathione peroxidase activity

determination method

1 reference

9 May 2019

Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

glutathione transferase activity

determination method

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

1 January 2018

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

1 January 2018

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

1 January 2018

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

glutathione transferase activity

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

glutathione transferase activity

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

sarcoplasmic reticulum

determination method

1 reference

9 May 2019

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

extracellular exosome

determination method

3 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

intercellular bridge

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

determination method

biological process

xenobiotic catabolic process

determination method

3 references

8 April 2019

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

glutathione metabolic process

determination method

3 references

8 April 2019

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

8 April 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

determination method

negative regulation of ryanodine-sensitive calcium-release channel activity

determination method

positive regulation of ryanodine-sensitive calcium-release channel activity

determination method

1 reference

9 May 2019

The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

cellular detoxification of nitrogen compound

determination method

nitrobenzene metabolic process

determination method

cellular response to caffeine

determination method

1 reference

9 May 2019

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28161&geneProductId=UniProtKB:P28161

determination method

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

determination method

1 reference

9 May 2019

The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

relaxation of cardiac muscle

determination method

1 reference

9 May 2019

Regulation of the cardiac muscle ryanodine receptor by glutathione transferases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

glutathione derivative biosynthetic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

determination method

1 reference

9 May 2019

The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

cellular oxidant detoxification

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

linoleic acid metabolic process

determination method

1 reference

9 May 2019

Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

glutathione metabolic process

determination method

4 references

9 May 2019

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

xenobiotic catabolic process

determination method

4 references

9 May 2019

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28161

determination method

Glutathione S-transferase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28161

glutathione S-transferase, C-terminal-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28161

Glutathione S-transferase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28161

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000241337

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000241337

ENSP00000416883

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416883

ENSP00000435910

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435910

ENSP00000358842

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000358842

ENSP00000358844

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000358844

ENSP00000358846

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000358846

ENSP00000404662

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404662

ENSP00000435157

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435157

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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