Protein arginine methyltransferase 5 (Q21130994)

Protein arginine N-methyltransferase PRMT5

1 reference

PRMT5, TIM barrel domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PRMT5 arginine-N-methyltransferase family

1 reference

based on heuristic

inferred from protein domain or family

PRMT5, oligomerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

methyltransferase activity

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

histone methyltransferase activity (H4-R3 specific)

1 reference

1 January 2018

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

transcription corepressor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 reference

1 January 2018

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

core promoter sequence-specific DNA binding

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

27 references

1 January 2018

HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Human fetal globin gene expression is regulated by LYAR.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Crystal structure of the human PRMT5:MEP50 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

A Y2H-seq approach defines the human protein methyltransferase interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Arginine methylation controls growth regulation by E2F-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Dynamic protein-protein interaction wiring of the human spliceosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

A novel WD repeat protein component of the methylosome binds Sm proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

protein heterodimerization activity

IPI

1 reference

1 January 2018

Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

ribonucleoprotein complex binding

1 reference

1 January 2018

Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

histone-arginine N-methyltransferase activity

IPI

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

protein-arginine N-methyltransferase activity

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

1 January 2018

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

1 January 2018

PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

identical protein binding

3 references

1 January 2018

Dynamic protein-protein interaction wiring of the human spliceosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Crystal structure of the human PRMT5:MEP50 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

A novel WD repeat protein component of the methylosome binds Sm proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

protein-containing complex binding

IPI

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

16 July 2018

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

16 July 2018

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

4 references

16 July 2018

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

16 July 2018

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

histone methyltransferase complex

1 reference

1 January 2018

Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

protein-containing complex

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

5 references

1 January 2018

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

regulation of mitotic nuclear division

IBA

biological process

1 reference

1 January 2018

Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

positive regulation of oligodendrocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

DNA-templated transcription, termination

1 reference

1 January 2018

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

negative regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

peptidyl-arginine N-methylation

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 January 2018

Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

endothelial cell activation

1 reference

1 January 2018

HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

circadian regulation of gene expression

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

transcription, DNA-templated

ISS

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

peptidyl-arginine methylation

1 reference

1 January 2018

Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

regulation of ERK1 and ERK2 cascade

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

regulation of DNA methylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

cell population proliferation

1 reference

1 January 2018

Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130

Golgi ribbon formation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

negative regulation of nucleic acid-templated transcription

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway

1 reference

1 January 2018

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

regulation of signal transduction by p53 class mediator

IGI

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

peptidyl-arginine methylation, to symmetrical-dimethyl arginine

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

chromatin organization

1 reference

1 January 2018

spliceosomal snRNP assembly

1 reference

1 January 2018

Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14744&geneProductId=UniProtKB:O14744

histone arginine methylation

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14744

reason for deprecated rank

IBA

EC enzyme number

2.1.1.125

deprecated identifier value

1 reference

PRMT5 arginine-N-methyltransferase

ENZYME

retrieved

22 April 2020

2.1.1.321

1 reference

22 April 2020

1 reference

PRMT5, TIM barrel domain

1 reference

PRMT5, oligomerisation domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016