High mobility group box 1 (Q21130552)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09429

High mobility group box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HMG box A DNA-binding domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

DNA-binding transcription factor activity

1 reference

17 October 2017

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

bubble DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

DNA polymerase binding

1 reference

8 April 2019

HMGB1 is a cofactor in mammalian base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

C-X-C chemokine binding

1 reference

8 April 2019

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

transcription factor binding

1 reference

17 October 2017

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

phosphatidylserine binding

1 reference

8 April 2019

High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

lipopolysaccharide binding

1 reference

8 April 2019

Identification of lipopolysaccharide‐binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

lyase activity

1 reference

8 April 2019

HMGB1 is a cofactor in mammalian base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

single-stranded DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

protein binding

11 references

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

High mobility group protein-1 (HMG-1) is a unique activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

Endogenous HMGB1 regulates autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

Evidence for involvement of HMGB1 protein in human DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

High mobility group protein-1 (HMG-1) is a unique activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

DNA binding, bending

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

17 October 2017

17 October 2017

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

supercoiled DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

four-way junction DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

RAGE receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

chemoattractant activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

RNA binding

double-stranded RNA binding

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

single-stranded RNA binding

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

calcium-dependent protein kinase regulator activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

protein kinase activator activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

double-stranded DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

transcription coactivator activity

1 reference

8 April 2019

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

cytokine activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

integrin binding

1 reference

8 April 2019

HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

DNA binding, bending

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

8 April 2019

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

cell component

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

transcription repressor complex

1 reference

8 April 2019

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

17 October 2017

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

17 October 2017

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

17 October 2017

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

cell surface

1 reference

8 April 2019

Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

condensed chromosome

1 reference

8 April 2019

Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

endoplasmic reticulum-Golgi intermediate compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

secretory granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

ficolin-1-rich granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

early endosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

neuron projection

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

8 April 2019

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

alphav-beta3 integrin-HMGB1 complex

1 reference

8 April 2019

HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

T-helper 1 cell activation

biological process

1 reference

8 April 2019

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

apoptotic DNA fragmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

regulation of transcription by RNA polymerase II

1 reference

17 October 2017

HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of DNA ligation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

positive regulation of JNK cascade

1 reference

8 April 2019

Structural basis for the proinflammatory cytokine activity of high mobility group box 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

apoptotic cell clearance

1 reference

8 April 2019

High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Effect of high mobility group box-1 protein on apoptosis of peritoneal macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of toll-like receptor 9 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

negative regulation of RNA polymerase II transcription preinitiation complex assembly

1 reference

8 April 2019

The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of dendritic cell differentiation

1 reference

8 April 2019

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of DNA binding

neuron projection development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

negative regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s)

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of interleukin-12 production

1 reference

8 April 2019

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of monocyte chemotaxis

1 reference

8 April 2019

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

activation of innate immune response

1 reference

17 October 2017

HMGB1–DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

DNA ligation involved in DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

positive regulation of MAPK cascade

1 reference

8 April 2019

Structural basis for the proinflammatory cytokine activity of high mobility group box 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of activated T cell proliferation

1 reference

8 April 2019

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

DNA geometric change

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

inflammatory response to antigenic stimulus

IEP

1 reference

8 April 2019

Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of interleukin-10 production

IEP

1 reference

8 April 2019

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

negative regulation of transcription by RNA polymerase II

1 reference

17 October 2017

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

regulation of restriction endodeoxyribonuclease activity

1 reference

8 April 2019

HMGB1 is a cofactor in mammalian base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

positive regulation of mismatch repair

1 reference

8 April 2019

Evidence for involvement of HMGB1 protein in human DNA mismatch repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

negative regulation of CD4-positive, alpha-beta T cell differentiation

1 reference

8 April 2019

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

T-helper 1 cell differentiation

1 reference

8 April 2019

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

dendritic cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

neutrophil clearance

1 reference

8 April 2019

High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

V(D)J recombination

1 reference

8 April 2019

V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of apoptotic process

1 reference

8 April 2019

Effect of high mobility group box-1 protein on apoptosis of peritoneal macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

DNA topological change

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

positive chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

eye development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of protein phosphorylation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

endothelial cell proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

plasmacytoid dendritic cell activation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

macrophage activation involved in immune response

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

base-excision repair

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

lung development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

activation of protein kinase activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of interferon-alpha production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of interferon-beta production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of interleukin-6 production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of tumor necrosis factor production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of toll-like receptor 2 signaling pathway

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of toll-like receptor 4 signaling pathway

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

endothelial cell chemotaxis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of innate immune response

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of myeloid cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of glycogen catabolic process

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

regulation of protein kinase activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

response to glucocorticoid

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of ERK1 and ERK2 cascade

positive regulation of wound healing

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of NIK/NF-kappaB signaling

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

positive regulation of sprouting angiogenesis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

negative regulation of apoptotic cell clearance

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

regulation of nucleotide-excision repair

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

regulation of signaling receptor activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429

negative regulation of transcription by RNA polymerase II

IGI

myeloid dendritic cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

activation of innate immune response

regulation of tolerance induction

1 reference

8 April 2019

Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

regulation of T cell mediated immune response to tumor cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

DNA recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

chromatin remodeling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

regulation of transcription by RNA polymerase II

regulation of signaling receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

regulation of autophagy

1 reference

8 April 2019

Endogenous HMGB1 regulates autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of autophagy

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

developmental process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of interleukin-6 production

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of innate immune response

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of transcription by RNA polymerase II

cell chemotaxis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of ERK1 and ERK2 cascade

cellular response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

1 reference

8 April 2019

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

positive regulation of vascular endothelial cell proliferation

1 reference

8 April 2019

miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

negative regulation of apoptotic cell clearance

1 reference

8 April 2019

HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

negative regulation of interferon-gamma production

1 reference

8 April 2019

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429

HMG box A DNA-binding domain, conserved site

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09429

High mobility group box domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09429

Identifiers

MeSH descriptor ID

D024243

subject named as

HMGB1 Protein

0 references

0 references

D12.776.660.235.400.600.300

broader concept

HMGB proteins

0 references

D12.776.664.235.400.600.300

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

archive URL

https://web.archive.org/web/20220125070108/https://docs.openalex.org/download-snapshot/snapshot-data-format

25 January 2022

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023