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Platelet derived growth factor subunit B (Q21123230)

From Wikidata
mammalian protein found in Homo sapiens
  • Platelet-derived growth factor beta polypeptide
  • epididymis secretory sperm binding protein
  • PDGF-2
  • platelet-derived growth factor 2
  • PDGF, B chain
  • proto-oncogene c-Sis
  • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
  • PDGFB
  • becaplermin
  • platelet-derived growth factor B chain
  • platelet-derived growth factor subunit B
  • platelet-derived growth factor, beta polypeptide (oncogene SIS)
  • PDGF subunit B
  • Proto-Oncogene Proteins c-sis
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    English
    Platelet derived growth factor subunit B
    mammalian protein found in Homo sapiens
    • Platelet-derived growth factor beta polypeptide
    • epididymis secretory sperm binding protein
    • PDGF-2
    • platelet-derived growth factor 2
    • PDGF, B chain
    • proto-oncogene c-Sis
    • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
    • PDGFB
    • becaplermin
    • platelet-derived growth factor B chain
    • platelet-derived growth factor subunit B
    • platelet-derived growth factor, beta polypeptide (oncogene SIS)
    • PDGF subunit B
    • Proto-Oncogene Proteins c-sis

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    7 references
    retrieved
    8 April 2019
    stated in
    Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    platelet-derived growth factor receptor binding
    determination method or standard
    IBA
    IDA
    IPI
    NAS
    5 references
    retrieved
    8 April 2019
    stated in
    Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A common PDGF receptor is activated by homodimeric A and B forms of PDGF
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IBA
    cell component
    biological process
    positive regulation of DNA biosynthetic process
    determination method or standard
    IDA
    7 references
    retrieved
    8 April 2019
    stated in
    Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    platelet-derived growth factor receptor signaling pathway
    determination method or standard
    IDA
    5 references
    retrieved
    1 January 2018
    stated in
    A common PDGF receptor is activated by homodimeric A and B forms of PDGF
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P01127&geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    positive regulation of MAP kinase activity
    determination method or standard
    IBA
    IDA
    5 references
    retrieved
    8 April 2019
    stated in
    c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P01127
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IBA
    platelet-derived growth factor receptor signaling pathway
    determination method or standard
    IBA
    IDA
    7 references
    retrieved
    8 April 2019
    stated in
    Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A common PDGF receptor is activated by homodimeric A and B forms of PDGF
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01127
    determination method or standard
    IBA

    Identifiers

    MeSH descriptor ID
    D020574
    subject named as
    Proto-Oncogene Proteins c-sis
    0 references
     
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