DLC1 Rho GTPase activating protein (Q21120521)

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mammalian protein found in Homo sapiens

epididymis secretory sperm binding protein
START domain-containing protein 12
deleted in liver cancer variant 4
Rho-GTPase-activating protein 7
HP protein
rho-type GTPase-activating protein 7
StAR-related lipid transfer protein 12
StARD12
StAR-related lipid transfer (START) domain containing 12
DLC-1
deleted in liver cancer 1 variant 2
rho GTPase-activating protein 7
DLC1
deleted in liver cancer 1 protein

Language	Label	Description	Also known as
English	DLC1 Rho GTPase activating protein	mammalian protein found in Homo sapiens	epididymis secretory sperm binding protein START domain-containing protein 12 deleted in liver cancer variant 4 Rho-GTPase-activating protein 7 HP protein rho-type GTPase-activating protein 7 StAR-related lipid transfer protein 12 StARD12 StAR-related lipid transfer (START) domain containing 12 DLC-1 deleted in liver cancer 1 variant 2 rho GTPase-activating protein 7 DLC1 deleted in liver cancer 1 protein

Statements

1 reference

13 November 2019

UniProt protein ID

START-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96QB1

Rho GTPase activation protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96QB1

Sterile alpha motif/pointed domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96QB1

Rho GTPase-activating protein 7

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96QB1

Rho GTPase-activating protein domain family

1 reference

based on heuristic

inferred from protein domain or family

Sterile alpha motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

START domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

SH2 domain binding

determination method

1 reference

8 April 2019

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

protein binding

determination method

4 references

8 April 2019

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

Charting the molecular links between driver and susceptibility genes in colorectal cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

GTPase activator activity

determination method

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QB1&geneProductId=UniProtKB:Q96QB1

determination method

5 June 2018

Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QB1&geneProductId=UniProtKB:Q96QB1

determination method

5 June 2018

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96QB1&geneProductId=UniProtKB:Q96QB1

determination method

GTPase activator activity

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

ruffle membrane

determination method

1 reference

8 April 2019

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

cortical actin cytoskeleton

determination method

1 reference

8 April 2019

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

determination method

1 reference

8 April 2019

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

determination method

1 reference

8 April 2019

Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

biological process

positive regulation of execution phase of apoptosis

determination method

1 reference

8 April 2019

Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

regulation of actin cytoskeleton organization

determination method

1 reference

8 April 2019

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

positive regulation of protein dephosphorylation

determination method

1 reference

8 April 2019

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

negative regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

heart morphogenesis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

focal adhesion assembly

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

neural tube closure

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

regulation of cell shape

determination method

1 reference

8 April 2019

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

hindbrain morphogenesis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

forebrain development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

negative regulation of stress fiber assembly

determination method

1 reference

8 April 2019

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

8 April 2019

Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

regulation of small GTPase mediated signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

negative regulation of focal adhesion assembly

determination method

1 reference

8 April 2019

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

actin cytoskeleton organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

negative regulation of cell population proliferation

determination method

3 references

8 April 2019

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

apoptotic process

determination method

1 reference

8 April 2019

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

negative regulation of cell migration

determination method

4 references

8 April 2019

DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

8 April 2019

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96QB1

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96QB1

Rho GTPase-activating protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96QB1

sterile alpha motif domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96QB1

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000276297

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000276297

ENSP00000321034

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000321034

ENSP00000351797

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000351797

ENSP00000422595

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422595

ENSP00000425878

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425878

ENSP00000428028

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428028

ENSP00000429537

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429537

ENSP00000473289

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473289

ENSP00000488100

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000488100

ENSP00000495198

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495198

ENSP00000495365

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495365

PDB structure ID

1 reference

UniProt protein ID

2 August 2016

language of work or name

1 reference

UniProt protein ID

2 August 2016

language of work or name

1 reference

UniProt protein ID

2 August 2016

language of work or name

1 reference

UniProt protein ID

2 August 2016

language of work or name

1 reference

UniProt protein ID

2 August 2016

language of work or name

1 reference

UniProt protein ID

2 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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