Arachidonate 15-lipoxygenase type B (Q21119941)

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mammalian protein found in Homo sapiens

arachidonate omega(6) lipoxygenase
1.13.11.-
arachidonate 15-lipoxygenase, second type
ALOX15B
15-LOX-2
arachidonate 15-lipoxygenase type II
arachidonate 15-lipoxygenase B
linoleate 13-lipoxygenase 15-LOb
15-lipoxygenase 2
arachidonate 15-lipoxygenase 2
15S-lipoxygenase
15-LOX-B

Language	Label	Description	Also known as
English	Arachidonate 15-lipoxygenase type B	mammalian protein found in Homo sapiens	arachidonate omega(6) lipoxygenase 1.13.11.- arachidonate 15-lipoxygenase, second type ALOX15B 15-LOX-2 arachidonate 15-lipoxygenase type II arachidonate 15-lipoxygenase B linoleate 13-lipoxygenase 15-LOb 15-lipoxygenase 2 arachidonate 15-lipoxygenase 2 15S-lipoxygenase 15-LOX-B

Statements

1 reference

13 November 2019

UniProt protein ID

Lipoxigenase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15296

PLAT/LH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15296

Lipoxygenase, mammalian

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15296

Lipoxygenase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, iron binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLAT/LH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

8 April 2019

The structure of human 15-lipoxygenase-2 with a substrate mimic

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

dioxygenase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

arachidonate 8(S)-lipoxygenase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

linoleate 13S-lipoxygenase activity

determination method

1 reference

8 April 2019

Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

oxidoreductase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

arachidonate 15-lipoxygenase activity

determination method

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

1 January 2018

Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

1 January 2018

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

1 January 2018

Discovery of a second 15S-lipoxygenase in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

1 January 2018

The structure of human 15-lipoxygenase-2 with a substrate mimic

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

arachidonate 15-lipoxygenase activity

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

The structure of human 15-lipoxygenase-2 with a substrate mimic

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Discovery of a second 15S-lipoxygenase in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

intracellular anatomical structure

determination method

1 reference

1 January 2018

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

extracellular exosome

determination method

1 reference

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15296&geneProductId=UniProtKB:O15296

determination method

extrinsic component of membrane

determination method

1 reference

8 April 2019

The structure of human 15-lipoxygenase-2 with a substrate mimic

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Subcellular Localization and Tumor-suppressive Functions of 15-Lipoxygenase 2 (15-LOX2) and Its Splice Variants

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

plasma membrane

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Subcellular Localization and Tumor-suppressive Functions of 15-Lipoxygenase 2 (15-LOX2) and Its Splice Variants

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

biological process

apoptotic process

determination method

1 reference

8 April 2019

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

linoleic acid metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

negative regulation of growth

determination method

1 reference

8 April 2019

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

positive regulation of keratinocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

negative regulation of cell cycle

determination method

1 reference

8 April 2019

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

prostate gland development

determination method

1 reference

8 April 2019

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

hepoxilin biosynthetic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

positive regulation of macrophage derived foam cell differentiation

determination method

1 reference

8 April 2019

Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

negative regulation of cell migration

determination method

1 reference

8 April 2019

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

positive regulation of peroxisome proliferator activated receptor signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

regulation of epithelial cell differentiation

determination method

1 reference

8 April 2019

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

negative regulation of cell population proliferation

determination method

arachidonic acid metabolic process

determination method

5 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

The structure of human 15-lipoxygenase-2 with a substrate mimic

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Discovery of a second 15S-lipoxygenase in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

8 April 2019

Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15296

determination method

EC enzyme number

1.13.11.-

1 reference

14 November 2015

http://www.uniprot.org/uniprot/O15296.txt?version=155

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000369520

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369520

ENSP00000369530

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369530

ENSP00000460332

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460332

ENSP00000458749

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458749

PDB structure ID

1 reference

UniProt protein ID

1 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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