Ribosomal protein S6 kinase A4 (Q21119246)

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mammalian protein found in Homo sapiens

RPS6KA4
ribosomal protein kinase B
RSKB
ribosomal protein S6 kinase alpha-4
90 kDa ribosomal protein S6 kinase 4
mitogen- and stress-activated protein kinase 2
ribosomal protein S6 kinase, 90kDa, polypeptide 4
nuclear mitogen- and stress-activated protein kinase 2

Language	Label	Description	Also known as
English	Ribosomal protein S6 kinase A4	mammalian protein found in Homo sapiens	RPS6KA4 ribosomal protein kinase B RSKB ribosomal protein S6 kinase alpha-4 90 kDa ribosomal protein S6 kinase 4 mitogen- and stress-activated protein kinase 2 ribosomal protein S6 kinase, 90kDa, polypeptide 4 nuclear mitogen- and stress-activated protein kinase 2

Statements

1 reference

13 November 2019

UniProt protein ID

ribosomal protein S6 kinase II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

Protein kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

AGC-kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

MSK2, N-terminal catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

protein serine/threonine kinase activity

determination method

4 references

27 March 2018

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75676&geneProductId=UniProtKB:O75676

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75676&geneProductId=UniProtKB:O75676

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75676&geneProductId=UniProtKB:O75676

determination method

27 March 2018

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75676&geneProductId=UniProtKB:O75676

determination method

ribosomal protein S6 kinase activity

determination method

1 reference

8 April 2019

C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

protein binding

determination method

3 references

8 April 2019

The protein interaction landscape of the human CMGC kinase group

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

magnesium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

protein serine/threonine kinase activity

determination method

5 references

8 April 2019

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

determination method

3 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75676&geneProductId=UniProtKB:O75676

determination method

27 March 2018

C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75676&geneProductId=UniProtKB:O75676

determination method

27 March 2018

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75676&geneProductId=UniProtKB:O75676

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

positive regulation of histone acetylation

determination method

1 reference

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

interleukin-1-mediated signaling pathway

determination method

1 reference

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

positive regulation of CREB transcription factor activity

determination method

1 reference

8 April 2019

MSK activation and physiological roles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

MSK activation and physiological roles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

inflammatory response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

negative regulation of cytokine production

determination method

1 reference

8 April 2019

MSK activation and physiological roles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

protein phosphorylation

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

intracellular signal transduction

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75676

determination method

AGC-kinase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

protein kinase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

MSK2, N-terminal catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75676

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000333896

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000333896

ENSP00000432945

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432945

ENSP00000435314

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435314

ENSP00000435580

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435580

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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