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Protein phosphatase 3 catalytic subunit beta (Q21118452)

From Wikidata

mammalian protein found in Homo sapiens

serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
protein phosphatase from PCR fragment H32
calmodulin-dependent calcineurin A subunit beta isoform
PPP3CB
CNA beta
calcineurin A beta
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
calcineurin A2
CAM-PRP catalytic subunit
protein phosphatase 3, catalytic subunit, beta isozyme
protein phosphatase 2B, catalytic subunit, beta isoform

Language	Label	Description	Also known as
default for all languages	No label defined
English	Protein phosphatase 3 catalytic subunit beta	mammalian protein found in Homo sapiens	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform protein phosphatase from PCR fragment H32 calmodulin-dependent calcineurin A subunit beta isoform PPP3CB CNA beta calcineurin A beta protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform calcineurin A2 CAM-PRP catalytic subunit protein phosphatase 3, catalytic subunit, beta isozyme protein phosphatase 2B, catalytic subunit, beta isoform

Statements

1 reference

13 November 2019

UniProt protein ID

Metallo-dependent phosphatase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16298

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase family

1 reference

based on heuristic

inferred from protein domain or family

Calcineurin-like phosphoesterase

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method or standard

1 reference

8 April 2019

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

phosphoprotein phosphatase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

protein dimerization activity

determination method or standard

1 reference

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

calmodulin binding

determination method or standard

5 references

16 July 2018

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Na+/H+ Exchanger 1 Directly Binds to Calcineurin A and Activates Downstream NFAT Signaling, Leading to Cardiomyocyte Hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

1 reference

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

protein phosphatase 2B binding

determination method or standard

1 reference

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

calmodulin-dependent protein phosphatase activity

determination method or standard

5 references

16 July 2018

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

calmodulin binding

determination method or standard

6 references

8 April 2019

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

calmodulin-dependent protein phosphatase activity

determination method or standard

6 references

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

calcineurin complex

determination method or standard

3 references

16 July 2018

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

16 July 2018

Na+/H+ Exchanger 1 Directly Binds to Calcineurin A and Activates Downstream NFAT Signaling, Leading to Cardiomyocyte Hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

glutamatergic synapse

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

calcineurin complex

determination method or standard

4 references

8 April 2019

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Na+/H+ Exchanger 1 Directly Binds to Calcineurin A and Activates Downstream NFAT Signaling, Leading to Cardiomyocyte Hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

biological process

response to cytokine

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

lymphangiogenesis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

regulation of insulin secretion

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

calcineurin-NFAT signaling cascade

determination method or standard

determination method or standard

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

regulation of synaptic plasticity

determination method or standard

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

T cell homeostasis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

negative regulation of T cell mediated cytotoxicity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

T cell proliferation

determination method or standard

1 reference

8 April 2019

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

Fc-epsilon receptor signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

development of the heart

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

T cell differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

determination method or standard

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

regulation of gene expression

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

social behavior

determination method or standard

1 reference

1 January 2018

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

locomotion involved in locomotory behavior

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

T cell activation

determination method or standard

1 reference

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Na+/H+ Exchanger 1 Directly Binds to Calcineurin A and Activates Downstream NFAT Signaling, Leading to Cardiomyocyte Hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

dephosphorylation

determination method or standard

1 reference

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

Wnt signaling pathway, calcium modulating pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

protein dephosphorylation

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

regulation of synaptic vesicle endocytosis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

calcineurin-mediated signaling

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method or standard

Calcineurin-like phosphoesterase domain, ApaH type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16298

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16298

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353881

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353881

ENSP00000378305

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378305

ENSP00000378306

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378306

ENSP00000343147

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000343147

ENSP00000398022

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000398022

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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