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HCK proto-oncogene, Src family tyrosine kinase (Q21113798)

From Wikidata
mammalian protein found in Homo sapiens
  • p59Hck
  • hemopoietic cell kinase
  • p61Hck
  • hematopoietic cell kinase
  • HCK
  • tyrosine-protein kinase HCK
  • p59-HCK/p60-HCK
  • Proto-Oncogene Proteins c-hck
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    English
    HCK proto-oncogene, Src family tyrosine kinase
    mammalian protein found in Homo sapiens
    • p59Hck
    • hemopoietic cell kinase
    • p61Hck
    • hematopoietic cell kinase
    • HCK
    • tyrosine-protein kinase HCK
    • p59-HCK/p60-HCK
    • Proto-Oncogene Proteins c-hck

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    21 references
    retrieved
    8 April 2019
    stated in
    Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
    GOA
    curator
    UniProt
    UniProt protein ID
    P08631
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK
    GOA
    curator
    UniProt
    UniProt protein ID
    P08631
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1
    GOA
    curator
    UniProt
    UniProt protein ID
    P08631
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A quantitative protein interaction network for the ErbB receptors using protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631
    determination method or standard
    IPI
    protein tyrosine kinase activity
    determination method or standard
    IEA
    IMP
    EXP
    TAS
    6 references
    retrieved
    7 November 2018
    stated in
    Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
    determination method or standard
    TAS
    retrieved
    7 November 2018
    stated in
    The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase
    GOA
    curator
    UniProt
    UniProt protein ID
    P08631
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
    determination method or standard
    IMP
    retrieved
    7 November 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P08631
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
    determination method or standard
    IEA
    retrieved
    7 November 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
    determination method or standard
    IEA
    retrieved
    7 November 2018
    stated in
    Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
    determination method or standard
    EXP
    retrieved
    7 November 2018
    stated in
    Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631
    determination method or standard
    EXP
    cell component
    biological process

    Identifiers

    MeSH descriptor ID
    D051572
    subject named as
    Proto-Oncogene Proteins c-hck
    0 references
    PDB structure ID
     
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