Hematopoietically expressed homeobox (Q21113391)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

sequence-specific DNA binding

2 references

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

protein homodimerization activity

1 reference

8 April 2019

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

DNA-binding transcription factor activity

IPI

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

HMG box domain binding

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

transcription factor binding

1 reference

8 April 2019

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

27 March 2018

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

4 references

8 April 2019

The transcriptional repressor protein PRH interacts with the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

DNA-binding transcription repressor activity, RNA polymerase II-specific

IPI

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

eukaryotic initiation factor 4E binding

1 reference

8 April 2019

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

TBP-class protein binding

1 reference

8 April 2019

CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

1 reference

8 April 2019

DNA wrapping and distortion by an oligomeric homeodomain protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

RNA polymerase II transcription regulatory region sequence-specific DNA binding

ISA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

DNA-binding transcription repressor activity, RNA polymerase II-specific

IBA

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

The transcriptional repressor protein PRH interacts with the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

1 reference

8 April 2019

DNA wrapping and distortion by an oligomeric homeodomain protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

The transcriptional repressor protein PRH interacts with the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

The transcriptional repressor protein PRH interacts with the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

IBA

biological process

Notch signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

myeloid leukocyte differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

DNA wrapping and distortion by an oligomeric homeodomain protein

DNA conformation change

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

primary lung bud formation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

multicellular organism growth

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

embryonic organ development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

regulation of transcription by RNA polymerase II

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

negative regulation of vascular endothelial growth factor receptor signaling pathway

2 references

27 March 2018

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

interkinetic nuclear migration

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

negative regulation of transcription by competitive promoter binding

1 reference

8 April 2019

CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

hepatocyte differentiation

TAS

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

in utero embryonic development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

negative regulation of transcription by RNA polymerase II

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

Expression and function of the homeodomain-containing protein Hex in thyroid cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

27 March 2018

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

Wnt signaling pathway

1 reference

8 April 2019

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

mRNA export from nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

embryonic heart tube development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

morphogenesis of an epithelium

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

poly(A)+ mRNA export from nucleus

1 reference

8 April 2019

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

IMP

forebrain morphogenesis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

hepatoblast differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

thyroid gland development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

common bile duct development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

regulation of cell population proliferation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

protein localization to nucleus

1 reference

8 April 2019

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

gall bladder development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

animal organ morphogenesis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

hepatic duct development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

negative regulation of transcription by transcription factor localization

1 reference

8 April 2019

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

IC

forebrain development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

cell population proliferation

1 reference

1 January 2018

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

negative regulation of transcription, DNA-templated

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Expression and function of the homeodomain-containing protein Hex in thyroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

primitive streak formation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Thyroid-specific transcription factors control Hex promoter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

response to peptide hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Expression and function of the homeodomain-containing protein Hex in thyroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03014&geneProductId=UniProtKB:Q03014

negative regulation of transcription by RNA polymerase II

3 references

8 April 2019

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Expression and function of the homeodomain-containing protein Hex in thyroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

anterior/posterior pattern specification

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

negative regulation of angiogenesis

1 reference

8 April 2019

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

positive regulation of Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

B cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

negative regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

regulation of leukocyte proliferation

1 reference

8 April 2019

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03014

has part(s)

Homeobox domain, metazoa

1 reference

Homeobox domain

1 reference

Homeobox, conserved site

1 reference