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MCL1 apoptosis regulator, BCL2 family member (Q21112678)

From Wikidata
mammalian protein found in Homo sapiens
  • mcl1/EAT
  • Bcl2-L-3
  • bcl-2-like protein 3
  • bcl-2-related protein EAT/mcl1
  • MCL1
  • myeloid cell leukemia sequence 1 (BCL2-related)
  • myeloid cell leukemia ES
  • myeloid cell leukemia 1
  • induced myeloid leukemia cell differentiation protein Mcl-1
  • MCL1, BCL2 family apoptosis regulator
  • BCL2 family apoptosis regulator
  • Myeloid Cell Leukemia Sequence 1 Protein
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    English
    MCL1 apoptosis regulator, BCL2 family member
    mammalian protein found in Homo sapiens
    • mcl1/EAT
    • Bcl2-L-3
    • bcl-2-like protein 3
    • bcl-2-related protein EAT/mcl1
    • MCL1
    • myeloid cell leukemia sequence 1 (BCL2-related)
    • myeloid cell leukemia ES
    • myeloid cell leukemia 1
    • induced myeloid leukemia cell differentiation protein Mcl-1
    • MCL1, BCL2 family apoptosis regulator
    • BCL2 family apoptosis regulator
    • Myeloid Cell Leukemia Sequence 1 Protein

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    26 references
    retrieved
    8 April 2019
    stated in
    The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07820
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Placental autophagy regulation by the BOK-MCL1 rheostat
    GOA
    curator
    UniProt
    UniProt protein ID
    Q07820
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human Bop is a novel BH3-only member of the Bcl-2 protein family
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07820
    determination method or standard
    IPI
    cell component
    biological process

    Identifiers

    MeSH descriptor ID
    D064549
    subject named as
    Myeloid Cell Leukemia Sequence 1 Protein
    0 references
    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q21112678&oldid=2383276503"