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autocrine motility factor receptor (Q21112658)

From Wikidata
mammalian protein found in Homo sapiens
  • RING finger protein 45
  • AMFR
  • gp78
  • AMF receptor
  • E3 ubiquitin-protein ligase AMFR
  • RING-type E3 ubiquitin transferase AMFR
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    English
    autocrine motility factor receptor
    mammalian protein found in Homo sapiens
    • RING finger protein 45
    • AMFR
    • gp78
    • AMF receptor
    • E3 ubiquitin-protein ligase AMFR
    • RING-type E3 ubiquitin transferase AMFR

    Statements

    molecular function
    ubiquitin-protein transferase activity
    determination method or standard
    IDA
    IMP
    5 references
    retrieved
    9 May 2019
    stated in
    Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IMP
    retrieved
    9 May 2019
    stated in
    Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IMP
    retrieved
    9 May 2019
    stated in
    Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IPI
    12 references
    retrieved
    9 May 2019
    stated in
    Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IPI
    cell component
    biological process
    ubiquitin-dependent ERAD pathway
    determination method or standard
    IDA
    TAS
    IMP
    4 references
    retrieved
    31 October 2017
    stated in
    Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    TAS
    retrieved
    31 October 2017
    stated in
    Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IMP
    retrieved
    31 October 2017
    stated in
    Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IDA
    retrieved
    31 October 2017
    stated in
    The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKV5&geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IDA
    ubiquitin-dependent ERAD pathway
    determination method or standard
    IC
    IDA
    IMP
    TAS
    5 references
    retrieved
    9 May 2019
    stated in
    Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    TAS
    retrieved
    9 May 2019
    stated in
    Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IMP
    retrieved
    9 May 2019
    stated in
    The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9UKV5
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
    determination method or standard
    IC

    Identifiers

    MeSH descriptor ID
    D060285
    subject named as
    Receptors, Autocrine Motility Factor
    0 references
     
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