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Chromobox 5 (Q21112513)

From Wikidata
mammalian protein found in Homo sapiens
  • CBX5
  • HP1 alpha
  • HP1Hs alpha
  • HP1 alpha homolog
  • chromobox protein homolog 5
  • heterochromatin protein 1-alpha
  • HP1-ALPHA
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
  • epididymis luminal protein 25
  • antigen p25
  • heterochromatin protein 1 homolog alpha
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    English
    Chromobox 5
    mammalian protein found in Homo sapiens
    • CBX5
    • HP1 alpha
    • HP1Hs alpha
    • HP1 alpha homolog
    • chromobox protein homolog 5
    • heterochromatin protein 1-alpha
    • HP1-ALPHA
    • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
    • epididymis luminal protein 25
    • antigen p25
    • heterochromatin protein 1 homolog alpha

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    33 references
    retrieved
    8 April 2019
    stated in
    Human BAHD1 promotes heterochromatic gene silencing
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Chromatin components as part of a putative transcriptional repressing complex
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Analysis of the human HP1 interactome reveals novel binding partners
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SET‐domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A High-Density Map for Navigating the Human Polycomb Complexome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A directed protein interaction network for investigating intracellular signal transduction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Heterochromatin links to centromeric protection by recruiting shugoshin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tudor, MBT and chromo domains gauge the degree of lysine methylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Pooled-matrix protein interaction screens using Barcode Fusion Genetics
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Chromatin components as part of a putative transcriptional repressing complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IPI
    cell component
    nucleus
    determination method or standard
    IEA
    IDA
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.
    GOA
    curator
    UniProt
    UniProt protein ID
    P45973
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Human Protein Atlas
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45973
    determination method or standard
    IDA
    biological process

    Identifiers

    MeSH descriptor ID
    D000090266
    subject named as
    Chromobox Protein Homolog 5
    0 references
     
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