Complement C1r (Q21111742)

Complement C1r subcomponent

1 reference

Peptidase S1, PA clan

1 reference

Sushi/SCR/CCP superfamily

1 reference

CUB domain, protein family

1 reference

Sushi/SCR/CCP domain, protein family

1 reference

Serine proteases, trypsin domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Serine proteases, trypsin family, serine active site, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

1 reference

16 January 2019

1 reference

16 January 2019

1 reference

8 April 2019

serine-type endopeptidase activity

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

26 September 2017

Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

26 September 2017

The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

3 references

8 April 2019

X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

8 April 2019

Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

8 April 2019

Ca2+ binding properties and Ca2(+)-dependent interactions of the isolated NH2-terminal alpha fragments of human complement proteases C1-r and C1-s

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

serine-type endopeptidase activity

4 references

8 April 2019

Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

8 April 2019

The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

8 April 2019

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

1 reference

26 September 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

IDA

extracellular exosome

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

1 reference

26 September 2017

Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

IDA

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

1 reference

8 April 2019

Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

2 references

immune system process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

innate immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

complement activation

1 reference

8 April 2019

regulation of complement activation

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00736

1 reference

26 September 2017

Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00736&geneProductId=UniProtKB:P00736

physically interacts with

IDA

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4262

EGF-type aspartate/asparagine hydroxylation site

English

retrieved

17 August 2016

has part(s)

1 reference

EGF-like calcium-binding, conserved site

1 reference

CUB domain

1 reference

EGF-like, conserved site

1 reference

serine proteases, trypsin domain

1 reference

sushi/SCR/CCP domain

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like domain

1 reference

Serine proteases, trypsin family, serine active site

1 reference

D12.776.124.486.274.045.280

Identifiers

MeSH descriptor ID

D015923

subject named as

Complement C1r

0 references

MeSH tree code

D08.811.277.300.280

0 references

0 references

D12.776.124.486.274.050.280

0 references

1 reference

16 November 2018

1 reference

22 March 2019

1 reference

16 January 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference