Insulin induced gene 1 (Q21110728)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15503

1 reference

13 November 2019

1 reference

13 November 2019

5 references

8 April 2019

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

8 April 2019

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

8 April 2019

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

8 April 2019

Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

8 April 2019

Progesterone Receptor Membrane Component 1 Inhibits the Activity of Drug-Metabolizing Cytochromes P450 and Binds to Cytochrome P450 Reductase

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

1 reference

8 April 2019

SREBP-SCAP-Insig complex

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

1 reference

8 April 2019

roof of mouth development

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

1 reference

8 April 2019

negative regulation of fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

sterol biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

negative regulation of fatty acid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

1 reference

8 April 2019

cholesterol metabolic process

response to sterol depletion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

cranial suture morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

negative regulation of cargo loading into COPII-coated vesicle

1 reference

8 April 2019

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

inner ear morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

middle ear morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

SREBP signaling pathway

1 reference

8 April 2019

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

cholesterol biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

cell population proliferation

TAS

1 reference

10 September 2018

Cloning, Human Chromosomal Assignment, and Adipose and Hepatic Expression of the CL-6/INSIG1 Gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15503&geneProductId=UniProtKB:O15503

triglyceride metabolic process

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

negative regulation of steroid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

cellular response to sterol

1 reference

8 April 2019

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

SREBP-SCAP complex retention in endoplasmic reticulum

1 reference

8 April 2019

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

cholesterol homeostasis

1 reference

8 April 2019

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503

negative regulation of protein exit from endoplasmic reticulum

1 reference

8 April 2019

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503