TIMP metallopeptidase inhibitor 1 (Q21109683)

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mammalian protein found in Homo sapiens

epididymis secretory sperm binding protein
collagenase inhibitor
TIMP-1
TIMP1
EPA
metalloproteinase inhibitor 1
Erythroid-potentiating activity
erythroid potentiating activity
tissue inhibitor of metalloproteinases 1
fibroblast collagenase inhibitor

Language	Label	Description	Also known as
English	TIMP metallopeptidase inhibitor 1	mammalian protein found in Homo sapiens	epididymis secretory sperm binding protein collagenase inhibitor TIMP-1 TIMP1 EPA metalloproteinase inhibitor 1 Erythroid-potentiating activity erythroid potentiating activity tissue inhibitor of metalloproteinases 1 fibroblast collagenase inhibitor

Statements

1 reference

13 November 2019

UniProt protein ID

Tissue inhibitor of metalloproteinases-like, OB-fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01033

metalloproteinase inhibitor 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01033

Proteinase inhibitor I35b (TIMP), C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01033

Netrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tissue inhibitor of metalloproteinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

peptidase inhibitor activity

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

enzyme inhibitor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

cytokine activity

determination method

1 reference

8 April 2019

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

protein binding

determination method

4 references

8 April 2019

The subject of epidemiology

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

Identification of binding partners interacting with the α1-N-propeptide of type V collagen.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

metalloendopeptidase inhibitor activity

determination method

5 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

17 October 2017

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

17 October 2017

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

17 October 2017

Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

growth factor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

zinc ion binding

determination method

1 reference

8 April 2019

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2: BINDING STUDIES AND CRYSTAL STRUCTURE

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

metalloendopeptidase inhibitor activity

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

extracellular matrix

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

extracellular region

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

basement membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

extracellular exosome

determination method

platelet alpha granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

endoplasmic reticulum lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

biological process

negative regulation of peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

response to peptide hormone

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

platelet degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

extracellular matrix disassembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

negative regulation of trophoblast cell migration

determination method

1 reference

8 April 2019

Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

response to organic substance

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

cell activation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

cartilage development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

regulation of integrin-mediated signaling pathway

determination method

1 reference

8 April 2019

Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

response to hormone

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

negative regulation of membrane protein ectodomain proteolysis

determination method

1 reference

17 October 2017

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

negative regulation of endopeptidase activity

determination method

1 reference

17 October 2017

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01033&geneProductId=UniProtKB:P01033

determination method

negative regulation of catalytic activity

determination method

1 reference

8 April 2019

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

negative regulation of metallopeptidase activity

determination method

1 reference

8 April 2019

Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

post-translational protein modification

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

connective tissue replacement involved in inflammatory response wound healing

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01033

determination method

negative regulation of membrane protein ectodomain proteolysis

determination method

Tissue inhibitor of metalloproteinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01033

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01033

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000218388

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000218388

ENSP00000366216

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366216

ENSP00000405380

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405380

ENSP00000406671

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406671

ENSP00000410983

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410983

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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