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Filamin A (Q21109662)

From Wikidata
mammalian protein found in Homo sapiens
  • endothelial actin-binding protein
  • non-muscle filamin
  • FLNA
  • epididymis secretory sperm binding protein
  • filamin A, alpha
  • Actin-binding protein 280
  • filamin-1
  • filamin-A
  • alpha-filamin
  • ABP-280
  • actin binding protein 280
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    English
    Filamin A
    mammalian protein found in Homo sapiens
    • endothelial actin-binding protein
    • non-muscle filamin
    • FLNA
    • epididymis secretory sperm binding protein
    • filamin A, alpha
    • Actin-binding protein 280
    • filamin-1
    • filamin-A
    • alpha-filamin
    • ABP-280
    • actin binding protein 280

    Statements

    molecular function
    actin filament binding
    determination method or standard
    IDA
    IEA
    5 references
    retrieved
    17 October 2017
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IEA
    retrieved
    17 October 2017
    stated in
    Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling
    GOA
    curator
    WormBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    protein binding
    determination method or standard
    IDA
    IPI
    32 references
    retrieved
    17 October 2017
    stated in
    Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling
    GOA
    curator
    WormBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    A meckelin-filamin A interaction mediates ciliogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Identification of Novel Nuclear Protein Interactions with the N-Terminal Part of Filamin A
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Interaction Between the μ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Structural mechanism of integrin inactivation by filamin.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Filamin A regulates cell spreading and survival via beta1 integrins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    The small GTPase RalA targets filamin to induce filopodia
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280)
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc Receptor I (FcγRI)
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    cell component
    extracellular exosome
    determination method or standard
    IDA
    5 references
    retrieved
    17 October 2017
    stated in
    Large-scale proteomics and phosphoproteomics of urinary exosomes
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Protein profile of exosomes from trabecular meshwork cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
    GOA
    curator
    UniProt
    UniProt protein ID
    P21333
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
    determination method or standard
    IDA
    biological process

    Identifiers

    PDB structure ID
     
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