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Cyclin A2 (Q21109659)

From Wikidata
mammalian protein found in Homo sapiens
  • CCNA2
  • cyclin-A
  • cyclin-A2
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    English
    Cyclin A2
    mammalian protein found in Homo sapiens
    • CCNA2
    • cyclin-A
    • cyclin-A2

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    22 references
    retrieved
    1 January 2018
    stated in
    Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P20248
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural basis of cyclin-dependent kinase activation by phosphorylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Simian virus 40 large T antigen associates with cyclin A and p33cdk2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The protein interaction landscape of the human CMGC kinase group
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IPI
    cell component
    nucleus
    determination method or standard
    IBA
    IDA
    IEA
    6 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P20248
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Cyclin A is required at two points in the human cell cycle
    GOA
    curator
    UniProt
    UniProt protein ID
    P20248
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IBA
    cyclin A2-CDK2 complex
    determination method or standard
    IBA
    IDA
    IEA
    6 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Cyclin A is required at two points in the human cell cycle
    GOA
    curator
    UniProt
    UniProt protein ID
    P20248
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
    determination method or standard
    IBA
    biological process

    Identifiers

    PDB structure ID
     
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