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Replication protein A1 (Q21109589)

From Wikidata
mammalian protein found in Homo sapiens
  • RPA1
  • MSTP075
  • replication protein A1, 70kDa
  • single-stranded DNA-binding protein
  • replication factor A protein 1
  • replication protein A 70 kDa DNA-binding subunit
  • RF-A protein 1
  • RP-A p70
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    English
    Replication protein A1
    mammalian protein found in Homo sapiens
    • RPA1
    • MSTP075
    • replication protein A1, 70kDa
    • single-stranded DNA-binding protein
    • replication factor A protein 1
    • replication protein A 70 kDa DNA-binding subunit
    • RF-A protein 1
    • RP-A p70

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    21 references
    retrieved
    8 April 2019
    stated in
    Activation of the ATR kinase by the RPA-binding protein ETAA1
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SLFN11 Blocks Stressed Replication Forks Independently of ATR.
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ETAA1 acts at stalled replication forks to maintain genome integrity
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional and physical interaction between WRN helicase and human replication protein A
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 modulates RPA-dependent and RPA-independent WRN helicase activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    hPrimpol1/CCDC111 is a human DNA primase‐polymerase required for the maintenance of genome integrity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    cell component
    DNA replication factor A complex
    determination method or standard
    IDA
    IEA
    IPI
    5 references
    retrieved
    17 October 2017
    stated in
    Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    17 October 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
    determination method or standard
    IEA
    retrieved
    17 October 2017
    stated in
    ETAA1 acts at stalled replication forks to maintain genome integrity
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
    determination method or standard
    IDA
    retrieved
    17 October 2017
    stated in
    Activation of the ATR kinase by the RPA-binding protein ETAA1
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P27694&geneProductId=UniProtKB:P27694
    determination method or standard
    IDA
    DNA replication factor A complex
    determination method or standard
    IBA
    IDA
    IEA
    IPI
    6 references
    retrieved
    8 April 2019
    stated in
    Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Activation of the ATR kinase by the RPA-binding protein ETAA1
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    ETAA1 acts at stalled replication forks to maintain genome integrity
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IBA
    biological process
    telomere maintenance
    determination method or standard
    IBA
    IC
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres
    GOA
    curator
    UniProt
    UniProt protein ID
    P27694
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IC
    retrieved
    8 April 2019
    stated in
    Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IC
    retrieved
    8 April 2019
    stated in
    Human replication protein A unfolds telomeric G-quadruplexes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IC
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27694
    determination method or standard
    IBA

    Identifiers

    PDB structure ID
     
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