BUB1 mitotic checkpoint serine/threonine kinase B (Q21108282)

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mammalian protein found in Homo sapiens
  • hBUBR1
  • MAD3/BUB1-related protein kinase
  • budding uninhibited by benzimidazoles 1 homolog beta
  • mitotic checkpoint kinase MAD3L
  • BUB1B
  • mitotic checkpoint serine/threonine-protein kinase BUB1 beta
  • Protein SSK1
  • BUB1B, mitotic checkpoint serine/threonine kinase
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Language Label Description Also known as
English
BUB1 mitotic checkpoint serine/threonine kinase B
mammalian protein found in Homo sapiens
  • hBUBR1
  • MAD3/BUB1-related protein kinase
  • budding uninhibited by benzimidazoles 1 homolog beta
  • mitotic checkpoint kinase MAD3L
  • BUB1B
  • mitotic checkpoint serine/threonine-protein kinase BUB1 beta
  • Protein SSK1
  • BUB1B, mitotic checkpoint serine/threonine kinase

Statements

molecular function
protein binding
determination method
IPI
23 references
retrieved
8 April 2019
stated in
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Systematic analysis of human protein complexes identifies chromosome segregation proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
retrieved
8 April 2019
stated in
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IPI
cell component
kinetochore
determination method
IEA
NAS
IDA
TAS
9 references
retrieved
16 July 2018
stated in
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
TAS
retrieved
16 July 2018
stated in
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
NAS
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
IEA
retrieved
16 July 2018
stated in
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
16 July 2018
stated in
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
16 July 2018
stated in
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
16 July 2018
stated in
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
16 July 2018
stated in
Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60566&geneProductId=UniProtKB:O60566
determination method
IDA
kinetochore
determination method
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IEA
retrieved
8 April 2019
stated in
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
8 April 2019
stated in
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
8 April 2019
stated in
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
GOA
curator
UniProt
UniProt protein ID
O60566
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
8 April 2019
stated in
Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IDA
retrieved
8 April 2019
stated in
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60566
determination method
IDA
biological process

Identifiers

 
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