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Damage specific DNA binding protein 1 (Q21108214)

From Wikidata
mammalian protein found in Homo sapiens
  • UV-damaged DNA-binding factor
  • DNA damage-binding protein a
  • damage-specific DNA binding protein 1, 127kDa
  • XPE-BF
  • UV-damaged DNA-binding protein 1
  • DDB1
  • DDBa
  • XAP-1
  • HBV X-associated protein 1
  • DNA damage-binding protein 1
  • UV-DDB 1
  • XPE-binding factor
  • DDB p127 subunit
  • Damage-specific DNA-binding protein 1
  • xeroderma pigmentosum group E-complementing protein
  • XPCe
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    English
    Damage specific DNA binding protein 1
    mammalian protein found in Homo sapiens
    • UV-damaged DNA-binding factor
    • DNA damage-binding protein a
    • damage-specific DNA binding protein 1, 127kDa
    • XPE-BF
    • UV-damaged DNA-binding protein 1
    • DDB1
    • DDBa
    • XAP-1
    • HBV X-associated protein 1
    • DNA damage-binding protein 1
    • UV-DDB 1
    • XPE-binding factor
    • DDB p127 subunit
    • Damage-specific DNA-binding protein 1
    • xeroderma pigmentosum group E-complementing protein
    • XPCe

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    31 references
    retrieved
    8 April 2019
    stated in
    Identification of a Primary Target of Thalidomide Teratogenicity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Selective degradation of splicing factor CAPERα by anticancer sulfonamides
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Viral immune modulators perturb the human molecular network by common and unique strategies
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
    GOA
    curator
    Developmental FunctionaL Annotation at Tufts
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IPI
    cell component
    Cul4A-RING E3 ubiquitin ligase complex
    determination method or standard
    IDA
    5 references
    retrieved
    8 April 2019
    stated in
    Identification of a Primary Target of Thalidomide Teratogenicity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    GOA
    curator
    UniProt
    UniProt protein ID
    Q16531
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16531
    determination method or standard
    IDA
    biological process

    Identifiers

    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q21108214&oldid=2022932834"