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Growth arrest and DNA damage inducible alpha (Q21108143)

From Wikidata

mammalian protein found in Homo sapiens

DDIT-1
growth arrest and DNA damage-inducible protein GADD45 alpha
DNA damage-inducible transcript 1 protein
DNA damage-inducible transcript-1
growth arrest and DNA-damage-inducible 45 alpha
GADD45A

Language	Label	Description	Also known as
default for all languages	No label defined
English	Growth arrest and DNA damage inducible alpha	mammalian protein found in Homo sapiens	DDIT-1 growth arrest and DNA damage-inducible protein GADD45 alpha DNA damage-inducible transcript 1 protein DNA damage-inducible transcript-1 growth arrest and DNA-damage-inducible 45 alpha GADD45A

Statements

1 reference

13 November 2019

UniProt protein ID

50S ribosomal protein L30e-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24522

Growth arrest and DNA damage-inducible protein GADD45

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24522

Ribosomal protein L7Ae/L30e/S12e/Gadd45, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

9 references

8 April 2019

TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Activation‐induced cytidine deaminase auto‐activates and triggers aberrant gene expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

protein heterodimerization activity

determination method or standard

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

protein N-terminus binding

determination method or standard

1 reference

8 April 2019

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

RNA polymerase II core promoter sequence-specific DNA binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

1 reference

16 July 2018

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

5 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method or standard

16 July 2018

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

biological process

apoptotic process

determination method or standard

1 reference

8 April 2019

Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

centrosome cycle

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

regulation of cyclin-dependent protein serine/threonine kinase activity

determination method or standard

1 reference

8 April 2019

The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

negative regulation of protein kinase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

signal transduction in response to DNA damage

determination method or standard

1 reference

8 April 2019

Feedback between p21 and reactive oxygen production is necessary for cell senescence

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

response to stress

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P24522&geneProductId=UniProtKB:P24522

determination method or standard

positive regulation of JNK cascade

determination method or standard

1 reference

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

positive regulation of reactive oxygen species metabolic process

determination method or standard

1 reference

8 April 2019

Feedback between p21 and reactive oxygen production is necessary for cell senescence

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

cellular response to ionizing radiation

determination method or standard

1 reference

8 April 2019

Feedback between p21 and reactive oxygen production is necessary for cell senescence

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

determination method or standard

1 reference

8 April 2019

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

positive regulation of p38MAPK cascade

determination method or standard

1 reference

8 April 2019

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24522

determination method or standard

regulation of cell cycle

determination method or standard

3 references

Ribosomal protein L7Ae/L30e/S12e/Gadd45

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24522

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000360024

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360024

ENSP00000360025

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360025

ENSP00000482814

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000482814

ENSP00000497697

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497697

ENSP00000496875

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496875

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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