protein kinase cGMP-dependent 1 (Q21106714)

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mammalian protein found in Homo sapiens

cGMP-dependent protein kinase I
protein kinase, cGMP-dependent, type I
protein kinase, cGMP-dependent, regulatory, type I, beta
cGMP-dependent protein kinase 1
cGKI
PRKG1

Language	Label	Description	Also known as
English	protein kinase cGMP-dependent 1	mammalian protein found in Homo sapiens	cGMP-dependent protein kinase I protein kinase, cGMP-dependent, type I protein kinase, cGMP-dependent, regulatory, type I, beta cGMP-dependent protein kinase 1 cGKI PRKG1

Statements

1 reference

13 November 2019

UniProt protein ID

Cyclic nucleotide-binding-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

RmlC-like jelly roll fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

cGMP-dependent kinase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

cGMP-dependent protein kinase, N-terminal coiled-coil domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

cGMP-dependent protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

AGC-kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cyclic nucleotide-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cyclic nucleotide-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

calcium channel regulator activity

determination method

1 reference

8 April 2019

Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

protein binding

determination method

5 references

8 April 2019

IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

8 April 2019

Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

8 April 2019

Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

8 April 2019

Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

catalytic activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

determination method

2 references

protein serine/threonine kinase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13976&geneProductId=UniProtKB:Q13976

determination method

identical protein binding

determination method

2 references

27 February 2018

A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13976&geneProductId=UniProtKB:Q13976

determination method

27 February 2018

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13976&geneProductId=UniProtKB:Q13976

determination method

protein kinase activity

determination method

1 reference

8 April 2019

MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

cGMP-dependent protein kinase activity

determination method

1 reference

8 April 2019

Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

biological process

negative regulation of smooth muscle contraction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

regulation of GTPase activity

determination method

1 reference

8 April 2019

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

dendrite development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

neuron migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

negative regulation of platelet aggregation

determination method

1 reference

8 April 2019

IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

cGMP-mediated signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

relaxation of vascular associated smooth muscle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

forebrain development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

actin cytoskeleton organization

determination method

1 reference

8 April 2019

Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

protein phosphorylation

determination method

negative regulation of vascular associated smooth muscle cell proliferation

determination method

1 reference

8 April 2019

MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

negative regulation of vascular associated smooth muscle cell migration

determination method

1 reference

8 April 2019

MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13976

determination method

Cyclic nucleotide-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

Cyclic nucleotide-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

AGC-kinase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

cGMP-dependent protein kinase, N-terminal coiled-coil domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

cGMP-dependent protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13976

Identifiers

MeSH descriptor ID

subject named as

Cyclic GMP-Dependent Protein Kinase Type I

0 references

D08.811.913.696.620.682.700.150.150.500

0 references

D12.776.476.563.150.150.500

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363092

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363092

ENSP00000363087

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363087

ENSP00000384200

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384200

ENSP00000496551

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496551

ENSP00000495279

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495279

ENSP00000494124

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494124

ENSP00000499822

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499822

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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