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RAS p21 protein activator 1 (Q21104745)

From Wikidata
mammalian protein found in Homo sapiens
  • Ras p21 protein activator
  • p120GAP
  • ras GTPase-activating protein 1
  • RASA1
  • RAS p21 protein activator (GTPase activating protein) 1
  • triphosphatase-activating protein
  • p120 RAS GTPase activating protein
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    English
    RAS p21 protein activator 1
    mammalian protein found in Homo sapiens
    • Ras p21 protein activator
    • p120GAP
    • ras GTPase-activating protein 1
    • RASA1
    • RAS p21 protein activator (GTPase activating protein) 1
    • triphosphatase-activating protein
    • p120 RAS GTPase activating protein

    Statements

    part of
    molecular function
    protein binding
    determination method or standard
    IPI
    19 references
    retrieved
    1 January 2018
    stated in
    Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
    GOA
    curator
    UniProt
    UniProt protein ID
    P20936
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P20936
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region
    GOA
    curator
    UniProt
    UniProt protein ID
    P20936
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
    GOA
    curator
    UniProt
    UniProt protein ID
    P20936
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A Ras-GTPase-activating protein SH3-domain-binding protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P20936
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Charting the molecular links between driver and susceptibility genes in colorectal cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A quantitative protein interaction network for the ErbB receptors using protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
    determination method or standard
    IPI
    cell component
    biological process

    Identifiers

     
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