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Phospholipase C gamma 1 (Q21104742)

From Wikidata
mammalian protein found in Homo sapiens
  • monophosphatidylinositol phosphodiesterase
  • phospholipase C-II
  • phospholipase C, gamma 1 (formerly subtype 148)
  • PLC-148
  • PLCG1
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  • phospholipase C-148
  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
  • Phospholipase C-gamma-1
  • phosphatidylinositol phospholipase C
  • phosphoinositidase C
  • PLC-gamma-1
  • inositoltrisphosphohydrolase
  • PLC-II
  • triphosphoinositide phosphodiesterase
  • phosphoinositide phospholipase C-gamma-1
  • phosphoinositide phospholipase C
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    English
    Phospholipase C gamma 1
    mammalian protein found in Homo sapiens
    • monophosphatidylinositol phosphodiesterase
    • phospholipase C-II
    • phospholipase C, gamma 1 (formerly subtype 148)
    • PLC-148
    • PLCG1
    • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
    • phospholipase C-148
    • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
    • Phospholipase C-gamma-1
    • phosphatidylinositol phospholipase C
    • phosphoinositidase C
    • PLC-gamma-1
    • inositoltrisphosphohydrolase
    • PLC-II
    • triphosphoinositide phosphodiesterase
    • phosphoinositide phospholipase C-gamma-1
    • phosphoinositide phospholipase C

    Statements

    part of
    molecular function
    protein binding
    determination method or standard
    IPI
    44 references
    retrieved
    16 July 2018
    stated in
    Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration
    GOA
    curator
    UniProt
    UniProt protein ID
    P19174
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB
    GOA
    curator
    UniProt
    UniProt protein ID
    P19174
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1
    GOA
    curator
    UniProt
    UniProt protein ID
    P19174
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    A quantitative protein interaction network for the ErbB receptors using protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Subsets of epidermal growth factor receptors during activation and endocytosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Functional interaction between c-Src and its mitotic target, Sam 68
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Fine specificity and molecular competition in SLAM family receptor signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Identification of amino acids in the N-terminal SH2 domain of phospholipase C gamma 1 important in the interaction with epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    16 July 2018
    stated in
    Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P19174&geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    protein binding
    determination method or standard
    IBA
    IPI
    45 references
    retrieved
    8 April 2019
    stated in
    Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration
    GOA
    curator
    UniProt
    UniProt protein ID
    P19174
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1
    GOA
    curator
    UniProt
    UniProt protein ID
    P19174
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB
    GOA
    curator
    UniProt
    UniProt protein ID
    P19174
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A quantitative protein interaction network for the ErbB receptors using protein microarrays
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional interaction between c-Src and its mitotic target, Sam 68
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Fine specificity and molecular competition in SLAM family receptor signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of amino acids in the N-terminal SH2 domain of phospholipase C gamma 1 important in the interaction with epidermal growth factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Subsets of epidermal growth factor receptors during activation and endocytosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19174
    determination method or standard
    IBA
    cell component
    biological process
    has part(s)

    Identifiers

     
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