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RAP1B, member of RAS oncogene family (Q21103244)

From Wikidata

mammalian protein found in Homo sapiens

RAS-related protein RAP1B
small GTP binding protein
Ras family small GTP binding protein RAP1B
GTP-binding protein smg p21B
ras-related protein Rap-1b
RAP1B

Language	Label	Description	Also known as
default for all languages	No label defined
English	RAP1B, member of RAS oncogene family	mammalian protein found in Homo sapiens	RAS-related protein RAP1B small GTP binding protein Ras family small GTP binding protein RAP1B GTP-binding protein smg p21B ras-related protein Rap-1b RAP1B

Statements

1 reference

13 November 2019

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61224

Ras-related protein Rap1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61224

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

1 reference

8 April 2019

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

8 April 2019

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

protein binding

determination method or standard

9 references

9 May 2019

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

WNT-3a modulates platelet function by regulating small GTPase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

GTPase activity

determination method or standard

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

4 references

9 May 2019

Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Molecular cloning of smg p21B and identification of smg p21 purified from bovine brain and human platelets as smg p21B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

cell-cell junction

determination method or standard

1 reference

9 May 2019

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

1 reference

9 May 2019

Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

determination method or standard

1 reference

9 May 2019

Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

extracellular exosome

determination method or standard

3 references

17 October 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61224&geneProductId=UniProtKB:P61224

determination method or standard

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61224&geneProductId=UniProtKB:P61224

determination method or standard

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61224&geneProductId=UniProtKB:P61224

determination method or standard

azurophil granule membrane

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

extracellular exosome

determination method or standard

plasma membrane

determination method or standard

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

biological process

establishment of endothelial barrier

determination method or standard

1 reference

9 May 2019

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

microvillus assembly

determination method or standard

1 reference

9 May 2019

Rap2A links intestinal cell polarity to brush border formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

regulation of cell junction assembly

determination method or standard

1 reference

9 May 2019

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

Rap protein signal transduction

determination method or standard

1 reference

17 October 2017

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61224&geneProductId=UniProtKB:P61224

determination method or standard

regulation of establishment of cell polarity

determination method or standard

1 reference

9 May 2019

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

cellular response to cAMP

determination method or standard

1 reference

8 April 2019

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

signal transduction

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

interleukin-12-mediated signaling pathway

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

small GTPase mediated signal transduction

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

cell population proliferation

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

response to carbohydrate

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

negative regulation of calcium ion-dependent exocytosis

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

cellular response to organic cyclic compound

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

cellular response to gonadotropin-releasing hormone

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

negative regulation of synaptic vesicle exocytosis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

Rap protein signal transduction

determination method or standard

3 references

9 May 2019

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61224

determination method or standard

small GTP-binding protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61224

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000250559

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000250559

ENSP00000377085

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377085

ENSP00000399986

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399986

ENSP00000439966

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000439966

ENSP00000440014

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440014

ENSP00000441275

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441275

ENSP00000444830

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444830

ENSP00000446318

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446318

ENSP00000368270

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368270

ENSP00000390972

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390972

ENSP00000401095

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401095

ENSP00000437415

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437415

ENSP00000438088

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438088

ENSP00000438311

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438311

ENSP00000440466

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440466

ENSP00000440635

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440635

ENSP00000440708

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440708

ENSP00000441952

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441952

ENSP00000443775

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443775

ENSP00000443851

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443851

ENSP00000444060

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444060

ENSP00000444467

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444467

ENSP00000444786

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444786

ENSP00000444924

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444924

ENSP00000445090

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445090

ENSP00000445138

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445138

ENSP00000445977

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445977

ENSP00000446027

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446027

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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