Rho/Rac guanine nucleotide exchange factor 18 (Q21101966)

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mammalian protein found in Homo sapiens

SA-RhoGEF
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
rho guanine nucleotide exchange factor 18
114 kDa Rho-specific guanine nucleotide exchange factor
Rho-specific guanine nucleotide exchange factor p114
septin-associated RhoGEF
p114RhoGEF
p114-Rho-GEF

Language	Label	Description	Also known as
English	Rho/Rac guanine nucleotide exchange factor 18	mammalian protein found in Homo sapiens	SA-RhoGEF ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 rho guanine nucleotide exchange factor 18 114 kDa Rho-specific guanine nucleotide exchange factor Rho-specific guanine nucleotide exchange factor p114 septin-associated RhoGEF p114RhoGEF p114-Rho-GEF

Statements

1 reference

13 November 2019

UniProt protein ID

Dbl homology (DH) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6ZSZ5

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6ZSZ5

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

ARHGEF18, PH domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Dbl homology (DH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

guanyl-nucleotide exchange factor activity

determination method

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6ZSZ5&geneProductId=UniProtKB:Q6ZSZ5

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6ZSZ5&geneProductId=UniProtKB:Q6ZSZ5

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6ZSZ5&geneProductId=UniProtKB:Q6ZSZ5

determination method

1 January 2018

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6ZSZ5&geneProductId=UniProtKB:Q6ZSZ5

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

guanyl-nucleotide exchange factor activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

8 April 2019

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

apical part of cell

determination method

1 reference

8 April 2019

Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

extracellular exosome

determination method

1 reference

31 October 2017

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6ZSZ5&geneProductId=UniProtKB:Q6ZSZ5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

apical plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

biological process

regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

regulation of small GTPase mediated signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

actin cytoskeleton organization

determination method

1 reference

8 April 2019

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

regulation of cell shape

determination method

1 reference

8 April 2019

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

small GTPase mediated signal transduction

determination method

1 reference

31 October 2017

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6ZSZ5&geneProductId=UniProtKB:Q6ZSZ5

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6ZSZ5

determination method

regulation of molecular function

determination method

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6ZSZ5&geneProductId=UniProtKB:Q6ZSZ5

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000319200

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000319200

ENSP00000352995

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352995

ENSP00000470729

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470729

ENSP00000471597

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471597

ENSP00000482647

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000482647

ENSP00000499655

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499655

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