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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Q21101932)

From Wikidata
mammalian protein found in Homo sapiens
  • transcription activator BRG1
  • protein brahma homolog 1
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
  • homeotic gene regulator
  • ATP-dependent helicase SMARCA4
  • global transcription activator homologous sequence
  • brahma protein-like 1
  • BAF190A
  • SNF2-beta
  • BRM/SWI2-related gene 1
  • nuclear protein GRB1
  • SNF2-like 4
  • SMARCA4
  • sucrose nonfermenting-like 4
  • BRG1-associated factor 190A
  • mitotic growth and transcription activator
  • protein BRG-1
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    English
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
    mammalian protein found in Homo sapiens
    • transcription activator BRG1
    • protein brahma homolog 1
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
    • homeotic gene regulator
    • ATP-dependent helicase SMARCA4
    • global transcription activator homologous sequence
    • brahma protein-like 1
    • BAF190A
    • SNF2-beta
    • BRM/SWI2-related gene 1
    • nuclear protein GRB1
    • SNF2-like 4
    • SMARCA4
    • sucrose nonfermenting-like 4
    • BRG1-associated factor 190A
    • mitotic growth and transcription activator
    • protein BRG-1

    Statements

    part of
    molecular function
    protein binding
    determination method or standard
    IPI
    28 references
    retrieved
    9 May 2019
    stated in
    BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Heterozygous variants in ACTL6A, encoding a component of the BAF complex, are associated with intellectual disability
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Dual role of NRSF/REST in activation and repression of the glucocorticoid response
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    REST repression of neuronal genes requires components of the hSWI.SNF complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    BAF60a interacts with p53 to recruit the SWI/SNF complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Telomerase modulates Wnt signalling by association with target gene chromatin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Selectivity of chromatin-remodelling cofactors for ligand-activated transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Identification of a polymorphic, neuron-specific chromatin remodeling complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Involvement of telomerase reverse transcriptase in heterochromatin maintenance
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IPI
    cell component
    nucleus
    determination method or standard
    IDA
    IEA
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    nucleus
    determination method or standard
    IBA
    IDA
    IEA
    7 references
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IEA
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IEA
    retrieved
    9 May 2019
    stated in
    Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
    GOA
    curator
    UniProt
    UniProt protein ID
    P51532
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51532
    determination method or standard
    IBA
    biological process

    Identifiers

    RefSeq protein ID
    Ensembl protein ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q21101932&oldid=2022917689"