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Receptor interacting serine/threonine kinase 1 (Q21101871)

From Wikidata
mammalian protein found in Homo sapiens
  • serine/threonine-protein kinase RIP
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • RIPK1
  • receptor-interacting protein 1
  • cell death protein RIP
  • RIP-1
  • receptor-interacting protein kinase 1
  • receptor-interacting serine/threonine-protein kinase 1
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    English
    Receptor interacting serine/threonine kinase 1
    mammalian protein found in Homo sapiens
    • serine/threonine-protein kinase RIP
    • receptor (TNFRSF)-interacting serine-threonine kinase 1
    • RIPK1
    • receptor-interacting protein 1
    • cell death protein RIP
    • RIP-1
    • receptor-interacting protein kinase 1
    • receptor-interacting serine/threonine-protein kinase 1

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    41 references
    retrieved
    8 April 2019
    stated in
    Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    WDFY 1 mediates TLR 3/4 signaling by recruiting TRIF
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SH3RF2 functions as an oncogene by mediating PAK4 protein stability
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TNF-alpha induces two distinct caspase-8 activation pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Casein kinase 1alpha interacts with RIP1 and regulates NF-kappaB activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    In silico prediction of physical protein interactions and characterization of interactome orphans
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A type III effector antagonizes death receptor signalling during bacterial gut infection
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ubiquitin‐specific protease 4 promotes TNF‐α‐induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IPI
    cell component
    biological process
    necroptosis
    determination method or standard
    IEA
    IMP
    ISS
    TAS
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    ISS
    retrieved
    8 April 2019
    stated in
    The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13546
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
    determination method or standard
    IEA

    Identifiers

     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q21101871&oldid=2022917538"