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BCL2 like 11 (Q21100273)

From Wikidata
mammalian protein found in Homo sapiens
  • BCL2L11
  • Bcl2-interacting mediator of cell death
  • bcl-2 interacting protein Bim
  • bcl-2 interacting mediator of cell death
  • bcl-2-related ovarian death agonist
  • BCL2-like 11 (apoptosis facilitator)
  • bcl-2-like protein 11
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    English
    BCL2 like 11
    mammalian protein found in Homo sapiens
    • BCL2L11
    • Bcl2-interacting mediator of cell death
    • bcl-2 interacting protein Bim
    • bcl-2 interacting mediator of cell death
    • bcl-2-related ovarian death agonist
    • BCL2-like 11 (apoptosis facilitator)
    • bcl-2-like protein 11

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    27 references
    retrieved
    8 April 2019
    stated in
    Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure homology and interaction redundancy for discovering virus-host protein interactions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RACK1 and CIS mediate the degradation of BimEL in cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    High-throughput methods to detect dimerization of Bcl-2 family proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BAX activation is initiated at a novel interaction site
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BAX-induced apoptosis can be initiated through a conformational selection mechanism
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521
    determination method or standard
    IPI
    cell component
    biological process

    Identifiers

    RefSeq protein ID
    Ensembl protein ID
    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q21100273&oldid=2396444156"