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Enhancer of zeste 2 polycomb repressive complex 2 subunit (Q21097530)

From Wikidata
mammalian protein found in Homo sapiens
  • lysine N-methyltransferase 6
  • ENX-1
  • enhancer of zeste homolog 2
  • EZH2
  • histone-lysine N-methyltransferase EZH2
  • Enhancer of Zeste Homolog 2 Protein
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    English
    Enhancer of zeste 2 polycomb repressive complex 2 subunit
    mammalian protein found in Homo sapiens
    • lysine N-methyltransferase 6
    • ENX-1
    • enhancer of zeste homolog 2
    • EZH2
    • histone-lysine N-methyltransferase EZH2
    • Enhancer of Zeste Homolog 2 Protein

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    26 references
    retrieved
    8 April 2019
    stated in
    O-GlcNAcylation regulates EZH2 protein stability and function
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Corepressor Protein CDYL Functions as a Molecular Bridge between Polycomb Repressor Complex 2 and Repressive Chromatin Mark Trimethylated Histone Lysine 27
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Y2H-seq approach defines the human protein methyltransferase interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Polycomb group protein EZH2 directly controls DNA methylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATRX directs binding of PRC2 to Xist RNA and Polycomb targets
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A High-Density Map for Navigating the Human Polycomb Complexome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The histone variant macroH2A is an epigenetic regulator of key developmental genes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IPI
    cell component
    ESC/E(Z) complex
    determination method or standard
    IDA
    IEA
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    O-GlcNAcylation regulates EZH2 protein stability and function
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q15910
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
    determination method or standard
    IDA
    biological process
    Commons category
    Enhancer of Zeste Homolog 2
    0 references

    Identifiers

    MeSH descriptor ID
    D000071221
    subject named as
    Enhancer of Zeste Homolog 2 Protein
    0 references
    RefSeq protein ID
     
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