The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide (Q21090025)

April 2022 Public Data File from Crossref

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The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

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BACE (beta-secretase) modulates the processing of APLP2 in vivo

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Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity

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Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

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Cathelicidins, multifunctional peptides of the innate immunity

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Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism

19 March 2017

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Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

19 March 2017

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The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19

19 March 2017

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Senile seminal vesicle amyloid is derived from semenogelin I

19 March 2017

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Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1

19 March 2017

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Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

19 March 2017

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beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

19 March 2017

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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

19 March 2017

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The antimicrobial peptides derived from chromogranin/secretogranin family, new actors of innate immunity

12 September 2017

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Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli

12 September 2017

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Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

12 September 2017

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Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

12 September 2017

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Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism.

12 September 2017

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Epidemiology of central nervous system mycoses

12 September 2017

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

12 September 2017

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Multifunctional antimicrobial peptides: therapeutic targets in several human diseases

12 September 2017

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Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study

12 September 2017

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Mitochondrial dysfunction and Alzheimer's disease

12 September 2017

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Detergent-like actions of linear amphipathic cationic antimicrobial peptides

12 September 2017

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The amyloid precursor protein and postnatal neurogenesis/neuroregeneration

12 September 2017

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The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Lactoferrin Glu561Asp facilitates secondary amyloidosis in the cornea

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

The nervous system and innate immunity: the neuropeptide connection

12 September 2017

1 reference

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Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases

12 September 2017

1 reference

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The role of inflammation in Alzheimer's disease

12 September 2017

1 reference

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Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

12 September 2017

1 reference

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Infiltration of the brain by pathogens causes Alzheimer's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Synergy and duality in peptide antibiotic mechanisms

12 September 2017

1 reference

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Pathogenesis of bacterial meningitis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Characterization of antibacterial COOH-terminal proenkephalin-A-derived peptides (PEAP) in infectious fluids. Importance of enkelytin, the antibacterial PEAP209-237 secreted by stimulated chromaffin cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Mechanisms of cell death induced by the neutrophil antimicrobial peptides alpha-defensins and LL-37.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Comparison of alamar blue and MTT assays for high through-put screening

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Endogenous antimicrobial peptides and skin infections in atopic dermatitis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

The gene defects responsible for familial Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Binding sites on tau proteins as components for antimicrobial peptides.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Naturally processed dermcidin-derived peptides do not permeabilize bacterial membranes and kill microorganisms irrespective of their charge.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

βA4 amyloid protein deposition in brain after head trauma

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Kinetics of aggregation of synthetic beta-amyloid peptide

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Amyloidosis of seminal vesicles and ejaculatory ducts: a histologic analysis of 21 cases among 447 prostatectomy specimens

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Virology. Alzheimer's risk factor also aids HIV.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-beta peptide.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Binding of LL-37 to model biomembranes: insight into target vs host cell recognition.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Microplate Alamar blue assay for susceptibility testing of Candida albicans biofilms.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Investigations into the ability of an oblique alpha-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Relationship between Helicobacter pylori infection and Alzheimer disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Basis for selectivity of cationic antimicrobial peptides for bacterial versus mammalian membranes

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

The antimicrobial peptide rCRAMP is present in the central nervous system of the rat.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Preassembly of membrane-active peptides is an important factor in their selectivity toward target cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

A novel localized amyloidosis associated with lactoferrin in the cornea.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Effects of aging and beta-amyloid on the properties of brain synaptic and mitochondrial membranes

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Interaction of amyloid beta-protein with anionic phospholipids: possible involvement of Lys28 and C-terminus aliphatic amino acids.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831066

10.1371/JOURNAL.PONE.0009505

29 November 2018

Identifiers

DOI

1 reference

347891

ADS bibcode

2010PLoSO...5.9505S

0 references

347891

1 reference

1 reference

1 reference