MRE11 homolog, double strand break repair nuclease (Q2073928)

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mammalian protein found in Homo sapiens
  • MRE11 homolog A
  • meiotic recombination 11 homolog 1
  • MRE11 homolog, double strand break repair nuclease A
  • MRE11 homolog A, double strand break repair nuclease
  • double-strand break repair protein MRE11A
  • AT-like disease
  • double-strand break repair protein MRE11
  • MRE11 meiotic recombination 11 homolog A
  • MRE11
  • MRE11 meiotic recombination 11-like protein A
  • meiotic recombination 11 homolog A
  • endo/exonuclease Mre11
  • MRE11 homolog 1
  • DNA recombination and repair protein
  • MRE11 double strand break repair nuclease A
edit
Language Label Description Also known as
English
MRE11 homolog, double strand break repair nuclease
mammalian protein found in Homo sapiens
  • MRE11 homolog A
  • meiotic recombination 11 homolog 1
  • MRE11 homolog, double strand break repair nuclease A
  • MRE11 homolog A, double strand break repair nuclease
  • double-strand break repair protein MRE11A
  • AT-like disease
  • double-strand break repair protein MRE11
  • MRE11 meiotic recombination 11 homolog A
  • MRE11
  • MRE11 meiotic recombination 11-like protein A
  • meiotic recombination 11 homolog A
  • endo/exonuclease Mre11
  • MRE11 homolog 1
  • DNA recombination and repair protein
  • MRE11 double strand break repair nuclease A

Statements

molecular function
DNA binding
determination method
IDA
1 reference
retrieved
17 October 2017
stated in
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
manganese ion binding
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
ATP-dependent DNA helicase activity
determination method
IMP
1 reference
retrieved
17 October 2017
stated in
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IMP
single-stranded DNA endodeoxyribonuclease activity
determination method
IDA
TAS
2 references
retrieved
17 October 2017
stated in
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
UniProt-GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
protein C-terminus binding
determination method
IPI
1 reference
retrieved
17 October 2017
stated in
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
protein binding
determination method
IPI
22 references
retrieved
17 October 2017
stated in
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
EXD2 promotes homologous recombination by facilitating DNA end resection
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
CDK targets Sae2 to control DNA-end resection and homologous recombination
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
ATRX dysfunction induces replication defects in primary mouse cells
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
Five dysfunctional telomeres predict onset of senescence in human cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
Crystal structure of human Mre11: understanding tumorigenic mutations
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
EXD2 promotes homologous recombination by facilitating DNA end resection
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
CtIP tetramer assembly is required for DNA-end resection and repair.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
retrieved
17 October 2017
stated in
TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
3'-5' exonuclease activity
determination method
IDA
IEA
TAS
4 references
retrieved
17 October 2017
stated in
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
UniProt-GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
retrieved
17 October 2017
stated in
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
UniProt-GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
nuclease activity
determination method
TAS
IEA
2 references
retrieved
17 October 2017
stated in
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
endonuclease activity
determination method
IEA
2 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
double-stranded DNA binding
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
ATM-dependent phosphorylation of nibrin in response to radiation exposure
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
endodeoxyribonuclease activity
determination method
IDA
TAS
3 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
UniProt-GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
exonuclease activity
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
hydrolase activity
determination method
IEA
2 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
cadherin binding
determination method
IDA
1 reference
retrieved
17 October 2017
stated in
E-cadherin interactome complexity and robustness resolved by quantitative proteomics
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
identical protein binding
determination method
IPI
1 reference
retrieved
17 October 2017
stated in
Crystal structure of human Mre11: understanding tumorigenic mutations
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IPI
cell component
site of double-strand break
determination method
IDA
1 reference
retrieved
17 October 2017
stated in
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
cytosol
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
PML body
determination method
IDA
ISS
IEA
3 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
ISS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
nuclear chromosome, telomeric region
determination method
IDA
ISS
IEA
5 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
ISS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
Purification of proteins associated with specific genomic Loci
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
retrieved
17 October 2017
stated in
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
retrieved
17 October 2017
stated in
A quantitative telomeric chromatin isolation protocol identifies different telomeric states
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
cell nucleus
determination method
TAS
IEA
4 references
retrieved
17 October 2017
stated in
ATM-dependent phosphorylation of nibrin in response to radiation exposure
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
cytoplasm
determination method
IDA
1 reference
retrieved
17 October 2017
stated in
E-cadherin interactome complexity and robustness resolved by quantitative proteomics
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
nucleoplasm
determination method
IDA
TAS
3 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Human Protein Atlas xx
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
chromosome, telomeric region
determination method
IEA
IDA
2 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
chromosome
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
Mre11 complex
determination method
IDA
IEA
NAS
TAS
4 references
retrieved
17 October 2017
stated in
A balance between elongation and trimming regulates telomere stability in stem cells
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
NAS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
RAD50 and NBS1 form a stable complex functional in DNA binding and tethering
UniProt-GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
biological process
reciprocal meiotic recombination
determination method
TAS
2 references
retrieved
17 October 2017
stated in
Isolation and characterization of the human MRE11 homologue
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
DNA recombination
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
telomere maintenance via telomerase
determination method
TAS
2 references
retrieved
17 October 2017
stated in
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
positive regulation of kinase activity
determination method
IDA
1 reference
retrieved
17 October 2017
stated in
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
intra-S DNA damage checkpoint
determination method
IBA
IEA
2 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IBA
telomeric 3' overhang formation
determination method
IMP
1 reference
retrieved
17 October 2017
stated in
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IMP
negative regulation of apoptotic process
determination method
IMP
1 reference
retrieved
17 October 2017
stated in
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IMP
chromosome organization
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
sister chromatid cohesion
determination method
IMP
1 reference
retrieved
17 October 2017
stated in
Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IMP
cellular response to DNA damage stimulus
determination method
IDA
IEA
2 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
UniProt-GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
positive regulation of telomere maintenance
determination method
IMP
1 reference
retrieved
17 October 2017
stated in
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IMP
DNA duplex unwinding
determination method
IMP
1 reference
retrieved
17 October 2017
stated in
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IMP
synapsis
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
negative regulation of DNA endoreduplication
determination method
IMP
1 reference
retrieved
17 October 2017
stated in
Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IMP
double-strand break repair
determination method
TAS
IEA
3 references
retrieved
17 October 2017
stated in
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
meiotic cell cycle
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
double-strand break repair via homologous recombination
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
positive regulation of protein autophosphorylation
determination method
IDA
1 reference
retrieved
17 October 2017
stated in
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
cell proliferation
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
mitotic G2 DNA damage checkpoint
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
viral process
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
double-strand break repair via nonhomologous end joining
determination method
IDA
TAS
3 references
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
UniProt-GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IDA
positive regulation of type I interferon production
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
regulation of mitotic recombination
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
Isolation and characterization of the human MRE11 homologue
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
DNA repair
determination method
TAS
IEA
3 references
retrieved
17 October 2017
stated in
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
retrieved
17 October 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P49959
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
nucleic acid phosphodiester bond hydrolysis
determination method
IEA
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
IEA
DNA double-strand break processing
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
strand displacement
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
DNA replication
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
DNA synthesis involved in DNA repair
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS
regulation of signal transduction by p53 class mediator
determination method
TAS
1 reference
retrieved
17 October 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P49959&geneProductId=UniProtKB:P49959
determination method
TAS

Identifiers

 

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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q2073928&oldid=665943077"