carfilzomib (Q15366934)

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chemical compound

Kyprolis®
PR-171
Carfilzomib

Language	Label	Description	Also known as
English	carfilzomib	chemical compound	Kyprolis® PR-171 Carfilzomib

Statements

type of chemical entity

0 references

chemical compound

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chemical structure

Carfilzomib.svg
512 × 245; 23 KB

0 references

719.425799 dalton

1 reference

language of work or name

Carfilzomib (English)

3 October 2016

chemical formula

C₄₀H₅₇N₅O₇

1 reference

language of work or name

Carfilzomib (English)

19 November 2016

canonical SMILES

CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

1 reference

language of work or name

Carfilzomib (English)

19 November 2016

isomeric SMILES

CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

1 reference

language of work or name

Carfilzomib (English)

19 November 2016

active ingredient in

1 reference

14 February 2018

World Health Organisation international non-proprietary name

carfilzomib (English)

1 reference

language of work or name

carfilzomib (English)

3 October 2016

physically interacts with

Proteasome 20S subunit beta 5

subject has role

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Proteasome 20S subunit alpha 8

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit beta 10

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit alpha 5

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit alpha 3

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit beta 5

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome subunit beta 11

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit alpha 7

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 26S subunit, non-ATPase 1

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit beta 6

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 26S subunit, non-ATPase 14

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit alpha 2

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit beta 8

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit alpha 6

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome subunit beta 1

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

Proteasome 20S subunit beta 2

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

pregnancy category

US pregnancy category D

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category D

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Carfilzomib

17 January 2017

Commons category

Carfilzomib

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Identifiers

InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

1 reference

language of work or name

Carfilzomib (English)

19 November 2016

BLMPQMFVWMYDKT-NZTKNTHTSA-N

2 references

language of work or name

Carfilzomib (English)

19 November 2016

ChEBI release 2020-09-01

CAS Registry Number

1 reference

Global Substance Registration System

language of work or name

carfilzomib (English)

19 November 2016

1 reference

language of work or name

Carfilzomib (English)

19 November 2016

1 reference

language of work or name

Carfilzomib (English)

19 November 2016

Reaxys registry number

12488950

1 reference

language of work or name

carfilzomib (English)

3 October 2016

mapping relation type

1 reference

language of work or name

CARFILZOMIB (English)

19 November 2016

1 reference

language of work or name

CARFILZOMIB (English)

19 November 2016

UniChem compound ID

1 reference

DSSTox substance ID

1 reference

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

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692-054-2

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

(αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide (English)

CAS no.: 868540-17-4 (English)

ECHA Substance Infocard ID

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

(αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide (English)

CAS no.: 868540-17-4 (English)

1 reference

language of work or name

Carfilzomib (English)

publication date

17 November 2015

Guide to Pharmacology Ligand ID

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

carfilzomib (English)

19 November 2016

MeSH concept ID

0 references

1 reference

Global Substance Registration System

language of work or name

carfilzomib (English)

19 November 2016

1 reference

language of work or name

Carfilzomib (English)

19 November 2016

1 reference

Global Substance Registration System

language of work or name

carfilzomib (English)

19 November 2016

MedlinePlus drug identifier

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PatientsLikeMe treatment ID

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1 reference

Global Substance Registration System

language of work or name

carfilzomib (English)

19 November 2016

Probes And Drugs ID

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1 reference

1 reference

language of work or name

carfilzomib (English)

3 October 2016

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Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

Global Substance Registration System

language of work or name

carfilzomib (English)

19 November 2016

WikiProjectMed ID

0 references

Sitelinks

Wikipedia(14 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Carfilzomib

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