H2A.X variant histone (Q14912340)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

1 reference

14 February 2019

damaged DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

protein binding

4 references

14 February 2019

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

cell component

XY body

12 references

14 February 2019

A mouse speciation gene encodes a meiotic histone H3 methyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

TOPAZ1, a germ cell specific factor, is essential for male meiotic progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Localization and regulation of murine Esco2 during male and female meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Disruption of Chtf18 Causes Defective Meiotic Recombination in Male Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Meiotic failure in male mice lacking an X-linked factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

The mouse polyubiquitin gene Ubb is essential for meiotic progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

replication fork

1 reference

14 February 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

condensed nuclear chromosome

5 references

14 February 2019

FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Meiotic cohesin complexes are essential for the formation of the axial element in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Meiosis in mice without a synaptonemal complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

male germ cell nucleus

1 reference

14 February 2019

Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

chromatin

5 references

14 February 2019

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

nucleus

14 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

ISO

14 February 2019

Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Silencing ofFem1cR3Gene Expression in the DBA/2J Mouse Precedes Retinal Ganglion Cell Death and Is Associated with Histone Deacetylase Activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Absence of mDazl produces a final block on germ cell development at meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

nucleoplasm

site of double-strand break

ISO

ISS

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Disruption of Chtf18 Causes Defective Meiotic Recombination in Male Mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Localization and regulation of murine Esco2 during male and female meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

site of DNA damage

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27661&geneProductId=UniProtKB:P27661

site of DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

1 reference

14 February 2019

double-strand break repair via homologous recombination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

1 reference

14 February 2019

DNA recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

1 reference

14 February 2019

DNA damage checkpoint signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

cellular response to DNA damage stimulus

ISO

3 references

DNA repair

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

14 February 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

cerebral cortex development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

cellular senescence

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27661&geneProductId=UniProtKB:P27661

4 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27661&geneProductId=UniProtKB:P27661

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27661&geneProductId=UniProtKB:P27661

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27661&geneProductId=UniProtKB:P27661

chromatin organization

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661

Histone H2A conserved site

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27661

Histone H2A/H2B/H3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27661

Histone H2A, C-terminal domain

1 reference

InterPro Release 71.0