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MutL homolog 1 (Q14911713)

From Wikidata
mammalian protein found in Mus musculus
  • DNA mismatch repair protein Mlh1
  • mutL protein homolog 1
  • colon cancer, nonpolyposis type 2
  • Mlh1
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    English
    MutL homolog 1
    mammalian protein found in Mus musculus
    • DNA mismatch repair protein Mlh1
    • mutL protein homolog 1
    • colon cancer, nonpolyposis type 2
    • Mlh1

    Statements

    molecular function
    cell component
    biological process
    cellular response to DNA damage stimulus
    determination method or standard
    IGI
    IEA
    IMP
    5 references
    retrieved
    14 February 2019
    stated in
    MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IGI
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q9JK91
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IEA
    DNA mismatch repair
    determination method or standard
    IDA
    IEA
    IMP
    ISO
    16 references
    retrieved
    16 July 2018
    stated in
    Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    ISO
    retrieved
    16 July 2018
    stated in
    Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    ISO
    retrieved
    16 July 2018
    stated in
    Meiotic pachytene arrest in MLH1-deficient mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JK91&geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IDA
    DNA mismatch repair
    determination method or standard
    IBA
    IDA
    IEA
    IMP
    ISO
    17 references
    retrieved
    14 February 2019
    stated in
    Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    Meiotic pachytene arrest in MLH1-deficient mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK91
    determination method or standard
    IBA

    Identifiers

     
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