Growth factor receptor bound protein 2 (Q14905190)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60631

Growth factor receptor-bound protein 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60631

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60631

membrane protein

1 reference

inferred from GOA cell component → membrane

GRB2, N-terminal SH3 domain, protein family

1 reference

GRB2, C-terminal SH3 domain, protein family

1 reference

SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

ISS

ISO

ephrin receptor binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

ISO

9 May 2019

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

protein binding

44 references

9 May 2019

Themis, a T cell-specific protein important for late thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

PrPC directly interacts with proteins involved in signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Gab3, a New DOS/Gab Family Member, Facilitates Macrophage Differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

'Srcasm: a Novel SrcActivating and SignalingMolecule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Prion protein interaction with the C-terminal SH3 domain of Grb2 studied using NMR and optical spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

protein phosphatase binding

1 reference

9 May 2019

Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

non-membrane spanning protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60631&geneProductId=UniProtKB:Q60631

1 reference

5 June 2018

protein domain specific binding

3 references

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

1 reference

9 May 2019

TAS

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

1 reference

9 May 2019

membrane

1 reference

9 May 2019

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

cell-cell junction

1 reference

9 May 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

vesicle membrane

1 reference

9 May 2019

Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

plasma membrane

1 reference

9 May 2019

Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

nucleoplasm

ISO

COP9 signalosome

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

extrinsic component of cytoplasmic side of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60631&geneProductId=UniProtKB:Q60631

1 reference

5 June 2018

biological process

cell differentiation

1 reference

9 May 2019

The Grb2/Mek pathway represses Nanog in murine embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

regulation of MAPK cascade

1 reference

9 May 2019

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

positive regulation of actin filament polymerization

1 reference

9 May 2019

Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

anatomical structure formation involved in morphogenesis

1 reference

9 May 2019

Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

branching involved in labyrinthine layer morphogenesis

1 reference

9 May 2019

Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

positive regulation of signal transduction

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60631&geneProductId=UniProtKB:Q60631

1 reference

5 June 2018

peptidyl-tyrosine autophosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60631&geneProductId=UniProtKB:Q60631

1 reference

5 June 2018

regulation of cell population proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60631&geneProductId=UniProtKB:Q60631

1 reference

5 June 2018

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60631&geneProductId=UniProtKB:Q60631

1 reference

5 June 2018

Ras protein signal transduction

TAS

1 reference

9 May 2019

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60631

TAS

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016