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Bone morphogenetic protein 2 (Q14903156)

From Wikidata
mammalian protein found in Mus musculus
  • bone morphogenetic protein 2
  • Bmp2
  • BMP-2A
  • bone morphogenetic protein 2A
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    English
    Bone morphogenetic protein 2
    mammalian protein found in Mus musculus
    • bone morphogenetic protein 2
    • Bmp2
    • BMP-2A
    • bone morphogenetic protein 2A

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    8 references
    retrieved
    8 April 2019
    stated in
    WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P21274
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization
    GOA
    curator
    UniProt
    UniProt protein ID
    P21274
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo
    GOA
    curator
    UniProt
    UniProt protein ID
    P21274
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IPI
    cell component
    biological process
    BMP signaling pathway
    determination method or standard
    IDA
    IGI
    IEA
    ISO
    8 references
    retrieved
    24 April 2018
    stated in
    Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    ISO
    retrieved
    24 April 2018
    stated in
    Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    IGI
    retrieved
    24 April 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    IEA
    retrieved
    24 April 2018
    stated in
    C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    24 April 2018
    stated in
    Akt promotes BMP2-mediated osteoblast differentiation and bone development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    osteoblast differentiation
    determination method or standard
    IDA
    IGI
    IEA
    ISO
    8 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    ISO
    retrieved
    8 April 2019
    stated in
    Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Akt promotes BMP2-mediated osteoblast differentiation and bone development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Akt promotes BMP2-mediated osteoblast differentiation and bone development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IDA
    IEA
    IMP
    ISO
    10 references
    retrieved
    8 April 2019
    stated in
    Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    ISO
    retrieved
    8 April 2019
    stated in
    Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    ISO
    retrieved
    8 April 2019
    stated in
    Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Analysis of Epithelial–Mesenchymal Interactions in the Initial Morphogenesis of the Mammalian Tooth
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Molecular mechanisms of cell and tissue interactions during early tooth development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    BMP signaling pathway
    determination method or standard
    IBA
    IDA
    IEA
    IGI
    ISO
    9 references
    retrieved
    8 April 2019
    stated in
    Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    ISO
    retrieved
    8 April 2019
    stated in
    Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Akt promotes BMP2-mediated osteoblast differentiation and bone development
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274
    determination method or standard
    IBA

    Identifiers

     
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