GLI-Kruppel family member GLI2 (Q14886550)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q0VGT2

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

DNA-binding transcription factor activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

5 June 2018

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0VGT2&geneProductId=UniProtKB:Q0VGT2

9 May 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

1 reference

9 May 2019

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

chromatin binding

1 reference

9 May 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

protein binding

6 references

9 May 2019

Physical and functional interactions between Zic and Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

1 reference

9 May 2019

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

3 references

9 May 2019

9 May 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

sequence-specific DNA binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

transcription factor binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The transcription factor Foxc1 is necessary for Ihh–Gli2-regulated endochondral ossification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

promoter-specific chromatin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The transcription factor Foxc1 is necessary for Ihh–Gli2-regulated endochondral ossification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cell component

cytoplasm

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

9 May 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

1 reference

9 May 2019

TAS

membrane

1 reference

9 May 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

nuclear speck

1 reference

9 May 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

axoneme

1 reference

9 May 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

ciliary tip

1 reference

9 May 2019

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

nucleus

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The transcription factor Foxc1 is necessary for Ihh–Gli2-regulated endochondral ossification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Physical and functional interactions between Zic and Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

motile cilium

1 reference

9 May 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cilium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

8 references

9 May 2019

9 May 2019

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

1 reference

9 May 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

1 reference

9 May 2019

pattern specification process

TAS

biological process

skeletal system development

1 reference

9 May 2019

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

smoothened signaling pathway involved in ventral spinal cord interneuron specification

1 reference

9 May 2019

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

notochord regression

1 reference

9 May 2019

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

anatomical structure formation involved in morphogenesis

1 reference

9 May 2019

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

spinal cord dorsal/ventral patterning

Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Gli1can rescue the in vivo function ofGli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

mammary gland development

1 reference

9 May 2019

The Gli2 Transcription Factor Is Required for Normal Mouse Mammary Gland Development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

prostatic bud formation

1 reference

9 May 2019

Functional compensation in Hedgehog signaling during mouse prostate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

negative regulation of chondrocyte differentiation

1 reference

9 May 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cell population proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

14 February 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

spinal cord ventral commissure morphogenesis

1 reference

9 May 2019

Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

floor plate formation

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0VGT2&geneProductId=UniProtKB:Q0VGT2

1 reference

5 June 2018

kidney development

1 reference

9 May 2019

Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

tube development

1 reference

9 May 2019

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

response to mechanical stimulus

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0VGT2&geneProductId=UniProtKB:Q0VGT2

embryonic digit morphogenesis

1 reference

9 May 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

head development

1 reference

9 May 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

neuron development

1 reference

9 May 2019

Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

in utero embryonic development

1 reference

9 May 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0VGT2&geneProductId=UniProtKB:Q0VGT2

1 reference

5 June 2018

mammary gland duct morphogenesis

1 reference

9 May 2019

The Gli2 Transcription Factor Is Required for Normal Mouse Mammary Gland Development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

morphogenesis of an epithelium

1 reference

9 May 2019

Functional compensation in Hedgehog signaling during mouse prostate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

positive regulation of transcription, DNA-templated

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

ventral midline development

development of the heart

1 reference

9 May 2019

Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

positive regulation of neuron differentiation

1 reference

9 May 2019

Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

neural tube development

1 reference

9 May 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

smoothened signaling pathway

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

spinal cord motor neuron differentiation

1 reference

9 May 2019

Complex interactions between genes controlling trafficking in primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

proximal/distal pattern formation

1 reference

9 May 2019

Complementary Gli activity mediates early patterning of the mouse visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cell differentiation

chondrocyte differentiation

1 reference

9 May 2019

IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

cellular response to organic cyclic compound

1 reference

9 May 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

negative regulation of apoptotic process

1 reference

9 May 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

negative regulation of transcription by RNA polymerase II

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

developmental growth

1 reference

9 May 2019

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

osteoblast development

dorsal/ventral neural tube patterning

2 references

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

dorsal/ventral pattern formation

1 reference

9 May 2019

Complementary Gli activity mediates early patterning of the mouse visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

branching morphogenesis of an epithelial tube

1 reference

9 May 2019

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

embryonic digestive tract development

1 reference

9 May 2019

New mouse models of congenital anorectal malformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

pituitary gland development

1 reference

9 May 2019

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

hindbrain development

A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

ventral spinal cord development

1 reference

9 May 2019

Gli1can rescue the in vivo function ofGli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

axon guidance

1 reference

9 May 2019

Ventral midline cells are required for the local control of commissural axon guidance in the mouse spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

1 reference

9 May 2019

regulation of smoothened signaling pathway

1 reference

14 February 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

smoothened signaling pathway involved in dorsal/ventral neural tube patterning

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

1 reference

9 May 2019

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cochlea morphogenesis

1 reference

9 May 2019

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

positive regulation of cell population proliferation

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Shh controls epithelial proliferation via independent pathways that converge on N-Myc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

anterior/posterior pattern specification

1 reference

9 May 2019

Limb anterior–posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

positive regulation of transcription by RNA polymerase II

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

9 May 2019

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

transcription by RNA polymerase II

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0VGT2&geneProductId=UniProtKB:Q0VGT2

epidermal cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

cellular response to virus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0VGT2

prostate gland development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0VGT2&geneProductId=UniProtKB:Q0VGT2

has part(s)

Zinc finger C2H2-type

1 reference

InterPro Release 71.0