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Lymphocyte protein tyrosine kinase (Q14885208)

From Wikidata
mammalian protein found in Mus musculus
  • lymphocyte cell-specific protein-tyrosine kinase
  • proto-oncogene tyrosine-protein kinase LCK
  • LSK
  • leukocyte C-terminal Src kinase
  • Lck
  • p56-LCK
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    English
    Lymphocyte protein tyrosine kinase
    mammalian protein found in Mus musculus
    • lymphocyte cell-specific protein-tyrosine kinase
    • proto-oncogene tyrosine-protein kinase LCK
    • LSK
    • leukocyte C-terminal Src kinase
    • Lck
    • p56-LCK

    Statements

    part of
    molecular function
    protein tyrosine kinase activity
    determination method or standard
    IEA
    ISS
    ISO
    EXP
    IMP
    IDA
    9 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P06240
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    ISS
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    ISO
    retrieved
    1 January 2018
    stated in
    LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P06240
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Characterization of Lnk. An adaptor protein expressed in lymphocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240
    determination method or standard
    EXP
    protein binding
    determination method or standard
    IPI
    15 references
    retrieved
    14 February 2019
    stated in
    HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P06240
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    CAML is a p56Lck-interacting protein that is required for thymocyte development
    GOA
    curator
    UniProt
    UniProt protein ID
    P06240
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Regulation of T cell development by the deubiquitinating enzyme CYLD
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Interaction of p56lck with CD4 in the yeast two-hybrid system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    CD45 and RPTPα display different protein tyrosine phosphatase activities in T lymphocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Lck availability during thymic selection determines the recognition specificity of the T cell repertoire
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Interactions between the amino‐terminal domain of p56lck and cytoplasmic domains of CD4 and CD8α in yeast
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IPI
    protein tyrosine kinase activity
    determination method or standard
    IDA
    IEA
    IMP
    ISO
    ISS
    8 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P06240
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    ISS
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    ISO
    retrieved
    14 February 2019
    stated in
    LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IMP
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P06240
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    Characterization of Lnk. An adaptor protein expressed in lymphocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240
    determination method or standard
    IDA
    cell component
    biological process

    Identifiers

     
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