SOS Ras/Rac guanine nucleotide exchange factor 1 (Q7392096)

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mammalian protein found in Homo sapiens
  • son of sevenless homolog 1
  • Son of Sevenless
  • guanine nucleotide exchange factor
  • SOS1
  • SOS-1
  • uniprot:Q07889
  • gingival fibromatosis, hereditary, 1
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Language Label Description Also known as
English
SOS Ras/Rac guanine nucleotide exchange factor 1
mammalian protein found in Homo sapiens
  • son of sevenless homolog 1
  • Son of Sevenless
  • guanine nucleotide exchange factor
  • SOS1
  • SOS-1
  • uniprot:Q07889
  • gingival fibromatosis, hereditary, 1

Statements

molecular function
protein binding
determination method
IPI
32 references
retrieved
8 April 2019
stated in
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
GOA
curator
UniProt
UniProt protein ID
Q07889
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Differential interactions of human Sos1 and Sos2 with Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Membrane-dependent signal integration by the Ras activator Son of sevenless
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
The structural basis of the activation of Ras by Sos
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of interactions of Nck with Sos and dynamin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
A novel proteomic screen for peptide-protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Sos-mediated activation of rac1 by p66shc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of Sos activity by intramolecular interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Subsets of epidermal growth factor receptors during activation and endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Structural analysis of autoinhibition in the Ras activator Son of sevenless
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Charting the molecular network of the drug target Bcr-Abl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE SOS1 212777 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D020837
subject named as
SOS1 Protein
0 references
PDB structure ID
 
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