RNA polymerase II subunit A (Q7119965)

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mammalian protein found in Homo sapiens
  • DNA-directed RNA polymerase II subunit A
  • polymerase (RNA) II subunit A
  • DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
  • 2.7.7.48
  • DNA-directed RNA polymerase II subunit RPB1
  • DNA-directed RNA polymerase III largest subunit
  • RNA polymerase II subunit B1
  • POLR2A
  • RNA-directed RNA polymerase II subunit RPB1
  • polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
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Language Label Description Also known as
English
RNA polymerase II subunit A
mammalian protein found in Homo sapiens
  • DNA-directed RNA polymerase II subunit A
  • polymerase (RNA) II subunit A
  • DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
  • 2.7.7.48
  • DNA-directed RNA polymerase II subunit RPB1
  • DNA-directed RNA polymerase III largest subunit
  • RNA polymerase II subunit B1
  • POLR2A
  • RNA-directed RNA polymerase II subunit RPB1
  • polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Statements

molecular function
protein binding
determination method
IPI
36 references
retrieved
8 April 2019
stated in
Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Structure and function of the human transcription elongation factor DSIF
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Structure and function of the human transcription elongation factor DSIF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The EHV-1 UL4 protein that tempers viral gene expression interacts with cellular transcription factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The interaction between EAP30 and ELL is modulated by MCM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The human PAF complex coordinates transcription with events downstream of RNA synthesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
retrieved
8 April 2019
stated in
The EHV-1 UL4 protein that tempers viral gene expression interacts with cellular transcription factors
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IPI
cell component
nucleus
determination method
NAS
IDA
IEA
5 references
retrieved
8 April 2019
stated in
The human gene encoding the largest subunit of RNA polymerase II
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IEA
retrieved
8 April 2019
stated in
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes
GOA
curator
UniProt
UniProt protein ID
P24928
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IDA
retrieved
8 April 2019
stated in
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IDA
retrieved
8 April 2019
stated in
The TBN Protein, which Is Essential for Early Embryonic Mouse Development, Is an Inducible TAFII Implicated In Adipogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24928
determination method
IDA
biological process
Gene Atlas image
PBB GE POLR2A 202725 at fs.png
732 × 530; 12 KB
0 references

Identifiers

PDB structure ID
 
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