Linker for activation of T cells (Q6554368)

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mammalian protein found in Homo sapiens

36 kDa phospho-tyrosine adapter protein
LAT
linker for activation of T-cells family member 1
36 kDa phospho-tyrosine adaptor protein
pp36
linker for activation of T cells, transmembrane adaptor
p36-38

Language	Label	Description	Also known as
English	Linker for activation of T cells	mammalian protein found in Homo sapiens	36 kDa phospho-tyrosine adapter protein LAT linker for activation of T-cells family member 1 36 kDa phospho-tyrosine adaptor protein pp36 linker for activation of T cells, transmembrane adaptor p36-38

Statements

1 reference

13 November 2019

UniProt protein ID

Linker-for-activation of T cells (LAT) protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43561

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

11 references

8 April 2019

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

Fine specificity and molecular competition in SLAM family receptor signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

protein kinase binding

determination method

1 reference

24 April 2018

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43561&geneProductId=UniProtKB:O43561

determination method

determination method

2 references

cell-cell junction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

mast cell granule

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

immunological synapse

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

biological process

intracellular signal transduction

determination method

1 reference

24 April 2018

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43561&geneProductId=UniProtKB:O43561

determination method

adaptive immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

homeostasis of number of cells

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

regulation of T cell activation

determination method

1 reference

24 April 2018

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43561&geneProductId=UniProtKB:O43561

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

lymphocyte homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

Fc-epsilon receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

immune response

determination method

1 reference

24 April 2018

Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43561&geneProductId=UniProtKB:O43561

determination method

integrin-mediated signaling pathway

determination method

1 reference

8 April 2019

Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

mast cell degranulation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

inflammatory response

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43561&geneProductId=UniProtKB:O43561

determination method

T cell receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

T cell activation

determination method

1 reference

8 April 2019

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

calcium-mediated signaling

determination method

1 reference

8 April 2019

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

positive regulation of protein kinase activity

determination method

1 reference

24 April 2018

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43561&geneProductId=UniProtKB:O43561

determination method

Ras protein signal transduction

determination method

1 reference

8 April 2019

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

positive regulation of signal transduction

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43561

determination method

immune response

determination method

positive regulation of protein kinase activity

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000354119

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354119

ENSP00000378841

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378841

ENSP00000378845

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378845

ENSP00000398793

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000398793

ENSP00000456761

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000456761

ENSP00000457036

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457036

ENSP00000454793

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454793

ENSP00000455728

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000455728

ENSP00000488120

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000488120

ENSP00000492142

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492142

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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