DNA methyltransferase 3 beta (Q5205795)

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mammalian protein found in Homo sapiens

• DNA MTase HsaIIIB
• DNA methyltransferase HsaIIIB
• DNA (cytosine-5-)-methyltransferase 3 beta
• DNMT3B
• DNA (cytosine-5)-methyltransferase 3B
• M.HsaIIIB
• DNA cytosine-5--methyltransferase 3 beta

edit

Language	Label	Description	Also known as
English	DNA methyltransferase 3 beta	mammalian protein found in Homo sapiens	DNA MTase HsaIIIB DNA methyltransferase HsaIIIB DNA (cytosine-5-)-methyltransferase 3 beta DNMT3B DNA (cytosine-5)-methyltransferase 3B M.HsaIIIB DNA cytosine-5--methyltransferase 3 beta

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UBC3

part of

Zinc finger, FYVE/PHD-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UBC3

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UBC3

C-5 cytosine methyltransferase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UBC3

DNA (cytosine-5)-methyltransferase 3B, ADD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PWWP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ADD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA methylase, C-5 cytosine-specific, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UBC3

encoded by

DNMT3B

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UBC3

molecular function

methyltransferase activity

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

DNA binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

transcription corepressor activity

determination method

IDA

IMP

2 references

retrieved

8 April 2019

stated in

DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IMP

retrieved

8 April 2019

stated in

Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IDA

DNA-methyltransferase activity

determination method

NAS

TAS

IEA

5 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

TAS

retrieved

8 April 2019

stated in

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

NAS

retrieved

8 April 2019

stated in

Genetic variation in ICF syndrome: evidence for genetic heterogeneity

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

NAS

retrieved

8 April 2019

stated in

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

chromatin binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

protein binding

determination method

IPI

10 references

retrieved

8 April 2019

stated in

Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

The Polycomb group protein EZH2 directly controls DNA methylation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

retrieved

8 April 2019

stated in

Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IPI

DNA (cytosine-5-)-methyltransferase activity

determination method

NAS

IDA

TAS

IEA

4 references

retrieved

8 April 2019

stated in

Cloning, expression and chromosome locations of the human DNMT3 gene family

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

TAS

retrieved

8 April 2019

stated in

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

retrieved

8 April 2019

stated in

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IDA

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

ISA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

ISA

histone deacetylase binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBC3&geneProductId=UniProtKB:Q9UBC3

determination method

IEA

intracellular membrane-bounded organelle

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IDA

nucleoplasm

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IDA

nucleus

determination method

IDA

IEA

TAS

4 references

retrieved

8 April 2019

stated in

Cloning, expression and chromosome locations of the human DNMT3 gene family

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

retrieved

8 April 2019

stated in

Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IDA

biological process

response to ionizing radiation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

C-5 methylation of cytosine

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

response to estradiol

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

response to hypoxia

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

cellular response to hyperoxia

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

negative regulation of transcription by RNA polymerase II

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IDA

response to activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

cellular response to dexamethasone stimulus

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

response to vitamin A

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

DNA methylation

determination method

NAS

TAS

IEA

4 references

retrieved

8 April 2019

stated in

Cloning, expression and chromosome locations of the human DNMT3 gene family

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

TAS

retrieved

8 April 2019

stated in

Genetic variation in ICF syndrome: evidence for genetic heterogeneity

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

NAS

retrieved

8 April 2019

stated in

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

methylation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

positive regulation of gene expression

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IMP

negative regulation of gene expression, epigenetic

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

TAS

positive regulation of histone H3-K4 methylation

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IMP

positive regulation of neuron differentiation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

negative regulation of histone H3-K9 methylation

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

GOA

curator

UniProt

UniProt protein ID

Q9UBC3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IMP

regulation of gene expression

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

response to caffeine

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

response to toxic substance

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

response to cocaine

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBC3

determination method

IEA

Gene Atlas image

PBB GE DNMT3B 220668 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

PWWP domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UBC3

DNA methylase, C-5 cytosine-specific, active site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UBC3

ADD domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UBC3

DNA (cytosine-5)-methyltransferase 3B, ADD domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UBC3

Identifiers

RefSeq protein ID

NP_001193984

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

NP_001193985

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

NP_008823

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

NP_787044

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

NP_787045

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

NP_787046

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

XP_011526955

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

XP_011526956

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1789

UniProt protein ID

Q9UBC3

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UBC3

Ensembl protein ID

ENSP00000412305

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000412305

ENSP00000201963

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000201963

ENSP00000313397

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000313397

ENSP00000328547

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000328547

ENSP00000337764

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000337764

ENSP00000403169

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000403169

PDB structure ID

3QKJ

1 reference

stated in

UniProt

UniProt protein ID

Q9UBC3

retrieved

9 August 2016

language of work or name

English

3FLG

1 reference

stated in

UniProt

UniProt protein ID

Q9UBC3

retrieved

9 August 2016

language of work or name

English

5CIU

1 reference

stated in

UniProt

UniProt protein ID

Q9UBC3

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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