Caspase 8 (Q5049059)

From Wikidata
Jump to navigation Jump to search
mammalian protein found in Homo sapiens
  • FADD-like ICE
  • caspase-8
  • MORT1-associated ced-3 homolog
  • caspase 8, apoptosis-related cysteine peptidase
  • FLICE
  • apoptotic cysteine protease
  • CASP8
  • caspase 8, apoptosis-related cysteine protease
  • MACH-alpha-1/2/3 protein
  • MACH-beta-1/2/3/4 protein
  • CAP4
  • FADD-homologous ICE/CED-3-like protease
  • MACH
  • apoptotic protease Mch-5
  • ICE-like apoptotic protease 5
edit
Language Label Description Also known as
English
Caspase 8
mammalian protein found in Homo sapiens
  • FADD-like ICE
  • caspase-8
  • MORT1-associated ced-3 homolog
  • caspase 8, apoptosis-related cysteine peptidase
  • FLICE
  • apoptotic cysteine protease
  • CASP8
  • caspase 8, apoptosis-related cysteine protease
  • MACH-alpha-1/2/3 protein
  • MACH-beta-1/2/3/4 protein
  • CAP4
  • FADD-homologous ICE/CED-3-like protease
  • MACH
  • apoptotic protease Mch-5
  • ICE-like apoptotic protease 5

Statements

molecular function
protein binding
determination method
IPI
51 references
retrieved
9 May 2019
stated in
Calcium binding of ARC mediates regulation of caspase 8 and cell death
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Casper is a FADD- and caspase-related inducer of apoptosis
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
GOA
curator
UniProt
UniProt protein ID
Q14790
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Involvement of caspase 8 and c-FLIPL in the proangiogenic effects of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
A type III effector antagonizes death receptor signalling during bacterial gut infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Yes and PI3K bind CD95 to signal invasion of glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
The role of receptor internalization in CD95 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
TNF-alpha induces two distinct caspase-8 activation pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
retrieved
9 May 2019
stated in
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14790
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE CASP8 213373 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q5049059&oldid=2022906848"