Bone morphogenetic protein 6 (Q4941569)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

27 March 2018

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

protein heterodimerization activity

1 reference

8 April 2019

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

transforming growth factor beta receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

regulation of apoptotic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

skeletal system development

1 reference

8 April 2019

Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

male genitalia development

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of aldosterone secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of endothelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

SMAD protein signal transduction

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

positive regulation of aldosterone biosynthetic process

1 reference

8 April 2019

Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

response to retinoic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of bone mineralization

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of pathway-restricted SMAD protein phosphorylation

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

cellular response to BMP stimulus

1 reference

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

response to magnesium ion

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

response to glucocorticoid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

endochondral ossification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

BMP signaling pathway

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

27 March 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22004&geneProductId=UniProtKB:P22004

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

cellular response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

cartilage development

1 reference

8 April 2019

positive regulation of chondrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

1 reference

8 April 2019

Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of neuron differentiation

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of protein secretion

1 reference

8 April 2019

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

NAS

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

type B pancreatic cell development

1 reference

8 April 2019

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of transcription by RNA polymerase II

5 references

8 April 2019

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of cell population proliferation

1 reference

8 April 2019

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

positive regulation of pathway-restricted SMAD protein phosphorylation

NAS

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

BMP signaling pathway

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

SMAD protein signal transduction

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22004

http://purl.uniprot.org/uniprot/P22004

Gene Atlas image

PBB GE BMP6 206176 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Transforming growth factor-beta, C-terminal

Identifiers.org

has part(s)

1 reference

TGF-beta, propeptide

1 reference

Transforming growth factor beta, conserved site

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D055418

subject named as

Bone Morphogenetic Protein 6

0 references

MeSH tree code

D12.644.276.954.200.600

0 references

D12.776.467.942.200.600

0 references

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

1 reference